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6 results for "FAK" in Products
FAK Products
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
Potent and selective FAK inhibitor
Chemical Name:
3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
Purity:
≥98%
Selective FAK inhibitor
Alternate Names:
Y15,NSC 677249
Chemical Name:
1,2,4,5-Benzenetetramine tetrahydrochloride
Dual FAK/PYK2 inhibitor
Chemical Name:
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
Purity:
≥98%
Potent FAK inhibitor; orally bioavailable
Chemical Name:
2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide
Purity:
≥98%
Dual FAK/PYK2 inhibitor
Chemical Name:
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
Purity:
≥98%
Potent focal adhesion kinase (FAK) inhibitor
Chemical Name:
2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide
Purity:
≥98%
