FAK Inhibitor 14

Product Description

FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. FAK Inhibitor 14 prevents FAK autophosphorylation at Y397 (IC₅₀ = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK Inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.

Solubility

Preparing Stock Solutions for FAK Inhibitor 14

The following data is based on the product molecular weight 284.01

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.69 mL	23.47 mL	46.95 mL
3.75 mM	0.94 mL	4.69 mL	9.39 mL
7.5 mM	0.47 mL	2.35 mL	4.69 mL
37.5 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hochwald A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009 PMID: 19571674
• Golubovskaya A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth. J.Med.Chem. 2008 PMID: 18989950