PF 573228
Tocris Bioscience, part of Bio-Techne | Catalog # 3239
Potent and selective FAK inhibitor
Key Product Details
Description
Potent and selective FAK inhibitor
Product Description
PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
491.49
Formula
C22H20F3N5O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
CAS Number
869288-64-2
PubChem ID
11612883
InChI Key
HESLKTSGTIBHJU-UHFFFAOYSA-N
SMILES
O=C(N3)CCC1=C3C=CC(NC2=NC(NCC4=CC=CC(S(=O)(C)=O)=C4)=C(C(F)(F)F)C=N2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.15 | 100 |
Preparing Stock Solutions
for PF 573228
The following data is based on the product molecular weight 491.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.17 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.07 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kostourou FAK-heterozygous mice display enhanced tumour angiogenesis. Nat.Commun. 2013 PMID: 23799510
- Slack-Davis Cellular characterization of a novel focal adhesion kinase inhibitor. J.Biol.Chem. 2007 PMID: 17395594
Product Specific Notices for PF 573228
For research use only
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