Key Product Details
Description: | Potent and selective FAK inhibitor |
Chemical Name: | 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 491.49 |
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Citations for PF 573228 (48)
Citations are publications that use Bio-Techne products. Selected citations for PF 573228 include:
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Kouam et al.
(2019)
The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.
Radiat Oncol.
14:25
PMID: 30717801 -
Beerli et al.
(2019)
Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility.
Nat Microbiol.
4:216
PMID: 30420785 -
Ahrendsen et al.
(2018)
The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.
J Neurosci.
38:787
PMID: 29217681 -
Bastounis et al.
(2018)
Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin.
Mol Biol Cell.
29:1571
PMID: 29718765 -
Keasey et al.
(2018)
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
J Cell Sci.
131
PMID: 29222114 -
Song
(2017)
Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling
PLoS One.
12(4):e0175159
PMID: 28406972 -
Sero and Bakal
(2017)
Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion.
Cell Syst.
4:84
PMID: 28065575 -
Fu et al.
(2017)
Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.
J Am Soc Nephrol.
28:785
PMID: 27612995 -
Alowayed et al.
(2016)
LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a
Cell Physiol Biochem.
39:815
PMID: 27497669 -
Rengarajan et al.
(2016)
Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.
Sci Rep.
12:e1005603
PMID: 27152864 -
Nasrollahi and Pathak
(2016)
Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices.
PLoS One.
6:18831
PMID: 26728047 -
Hennigan et al.
(2016)
Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling
Clinical Immunology.
171:1
PMID: 27519953 -
Frolov et al.
(2016)
Imatinib and nilo. increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.
Sci Rep.
6:27378
PMID: 27293031 -
Du et al.
(2016)
Extracellular matrix stiffness dictates Wnt expression through integrin pathway.
Sci Rep.
6:20395
PMID: 26854061 -
Roa-Espitia et al.
(2016)
Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation.
Biol Open.
5:1189
PMID: 27402964 -
Wang et al.
(2016)
Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2.
Br J Pharmacol.
173:3342
PMID: 27638545 -
Webber et al.
(2015)
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
Oncoscience.
2:765
PMID: 26501082 -
Gu et al.
(2015)
Defective apical extrusion signaling contributes to aggressive tumor hallmarks.
Elife.
4:e04069
PMID: 25621765 -
Zhang et al.
(2015)
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Redox Biol.
5:10468
PMID: 26020477 -
Carrim et al.
(2015)
Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.
J Exp Med.
6:640
PMID: 26569550 -
Cheng et al.
(2015)
IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
Sci Rep.
212:513
PMID: 25779634 -
Robinson et al.
(2015)
Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
PLoS One.
10:e0143798
PMID: 26630674 -
Ji et al.
(2015)
WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways.
Br J Cancer.
113:921
PMID: 26291058 -
Alao et al.
(2014)
Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
BMC Cancer.
14:853
PMID: 25409876 -
Flannagan et al.
(2014)
The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis.
Mol Biol Cell.
25:1511
PMID: 24623723 -
Wrighton et al.
(2014)
Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
PLoS Pathog.
111:18126
PMID: 25422477 -
Shih et al.
(2014)
Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.
J Biol Chem.
34:2438
PMID: 24523534 -
Deevi et al.
(2014)
Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.
Neoplasia.
16:422
PMID: 24863845 -
Keasey et al.
(2013)
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Cell Commun Signal.
11:35
PMID: 23693126 -
Wiel et al.
(2013)
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Cell Death Dis.
4:e855
PMID: 24113189 -
Chapman et al.
(2013)
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.
J Immunol.
191:6208
PMID: 24227778 -
Yamashita et al.
(2013)
Periostin links mechanical strain to inflammation in abdominal aortic aneurysm.
J Neurosci.
8:e79753
PMID: 24260297 -
Quint et al.
(2013)
Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.
PLoS One.
288:5398
PMID: 23300082 -
Garrison et al.
(2013)
Reversal of myofibroblast differentiation by prostaglandin E(2).
Mol Cancer Ther.
48:550
PMID: 23470625 -
Barbelanne et al.
(2013)
Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.
Hum Mol Genet.
22:2482
PMID: 23446637 -
Curtis et al.
(2013)
Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction.
Biomech Model Mechanobiol.
12:95
PMID: 22407215 -
Beauséjour et al.
(2012)
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.
Apoptosis.
17:566
PMID: 22402981 -
Chu et al.
(2012)
Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway.
J Signal Transduct.
2012:473410
PMID: 22900166 -
Wong et al.
(2012)
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.
Am J Respir Cell Mol Biol.
18:148
PMID: 22157678 -
Guessous et al.
(2012)
Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.
Mol Cancer.
11:288
PMID: 22188814 -
Daley et al.
(2011)
A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis.
Dev Dyn.
240:2069
PMID: 22016182 -
Canonici et al.
(2011)
Saccharomyces boulardii improves intestinal cell restitution through activation of the α2β1 integrin collagen receptor.
Hepatology.
6:e18427
PMID: 21483797 -
Schrader et al.
(2011)
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.
Biochem Biophys Res Commun.
53:1192
PMID: 21442631 -
Huang et al.
(2011)
β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapa.
Breast Cancer Res.
13:R84
PMID: 21884573 -
Hao et al.
(2010)
tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.
Am J Pathol.
177:1164
PMID: 20639453 -
Tu et al.
(2010)
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
J Neurosci.
30:749
PMID: 20071540 -
Ocak et al.
(2010)
DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.
Oncogene.
29:6331
PMID: 20802517 -
Jones et al.
(2009)
Characterization of a novel focal adhesion kinase inhibitor in human platelets.
Nat Med.
389:198
PMID: 19716803
There are no citations that match your criteria.
Customer Reviews for PF 573228 (3)
Customer Images
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Species: RatAssay Type: In VitroCell Line/Tissue: rat astroglioma C6 cellspharmacological antagonists of FAK for 4 h before RNA or protein isolation. FAK antagonists were PF573228
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Species: MouseAssay Type: In VitroCell Line/Tissue: E0771Extracellular flux analysis (Seahorse experiments) of breast cancer cells. 5uM dose used for 48hrs
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Species: HumanEffective at inhibiting FAK expression when used in 2D (monolayer) and 3D (spheroid/microtissue) cell culture
There are no reviews that match your criteria.