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FAK Products
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
17 results for "FAK" in Products
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FAK Products
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
17 results for "FAK" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #495919 |
| Applications : | Immunohistochemistry, Knockout Validated, Simple Western, Western Blot |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
| Chemical Name : | 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #820755 |
| Applications : | Western Blot |
Potent and selective FAK inhibitor
| Chemical Name : | 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone |
| Purity : | ≥98% (HPLC) |
Potent FAK inhibitor; orally bioavailable
| Chemical Name : | 2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide |
| Purity : | ≥98% (HPLC) |
Potent focal adhesion kinase (FAK) inhibitor
| Chemical Name : | 2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide |
| Purity : | ≥98% (HPLC) |
Potent and selective FAK and Pyk2 inhibitor
| Chemical Name : | N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide |
| Purity : | ≥98% (HPLC) |
Selective FAK inhibitor
| Alternate Names : | Y15, NSC 677249 |
| Chemical Name : | 1,2,4,5-Benzenetetramine tetrahydrochloride |
| Source : | Sf 9 (baculovirus) |
| Accession # : | NM_153831 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Immunohistochemistry, Knockout Validated, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #743101 |
| Applications : | Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #743234 |
| Applications : | Western Blot |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Western Blot |
Potent and selective focal adhesion kinase (FAK) degrader
| Chemical Name : | (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Dual FAK/PYK2 inhibitor
| Chemical Name : | N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
| Purity : | ≥98% (HPLC) |
