PND 1186

Tocris Bioscience, part of Bio-Techne | Catalog # 6891

Potent FAK inhibitor; orally bioavailable
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Key Product Details

Description

Potent FAK inhibitor; orally bioavailable

View all Focal Adhesion Kinase Inhibitors »

Product Description

PND 1186 is a potent FAK inhibitor (IC50 values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.

Product Specifications

Molecular Weight

501.51

Formula

C25H26F3N5O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide

CAS Number

1061353-68-1

PubChem ID

25073775

InChI Key

IGUBBWJDMLCRIK-UHFFFAOYSA-N

SMILES

CNC(=O)C1=C(NC2=CC(NC3=C(OC)C=C(C=C3)N3CCOCC3)=NC=C2C(F)(F)F)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.15 100

Preparing Stock Solutions for PND 1186

The following data is based on the product molecular weight 501.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.40 mL 1.99 mL 3.99 mL
10 mM 0.20 mL 1.00 mL 1.99 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PND 1186

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PND 1186

For research use only

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