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EGFR Products

EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.

111 results for "EGFR" in Products

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EGFR Products

EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.

111 results for "EGFR" in Products

Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins

Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies

WB, Simple Western, Flow, IHC, IP, CyTOF-ready, ICC

Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies

Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies

Orally active, selective EGFR inhibitor

Analyzed by SEC-MALS

Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

BA

HEK293 Expressed

BA

Biotinylated

Potent EGFR PROTAC®; also degrades HER2

Potent, reversible EGFR tyrosine kinase inhibitor

Catalog #: MAGH124

Recombinant Monoclonal Antibody For Research Use Only

WB, Simple Western, IHC

Iressa synthesized to Ancillary Material Grade

Flow

Recombinant Monoclonal Antibody For Research Use Only

BA
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