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EGFR Products
EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.
114 results for "EGFR" in Products
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EGFR Products
EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.
114 results for "EGFR" in Products
Bind
Analyzed by SEC-MALS
| Source : | NS0 |
| Accession # : | CAA25240.1 |
| Applications : | Binding Activity |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
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Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Catalog #:
ARY027
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
Catalog #:
MAB9577
Flow, CyTOF-ready
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | CyTOF-ready, Flow Cytometry |
Flow, ICC
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
| Alternate Names : | BIBW2992 |
| Chemical Name : | (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate |
| Purity : | ≥98% (HPLC) |
BA
| Source : | NS0 |
| Accession # : | CAA25240 |
| Applications : | Bioactivity |
ELISA
| Sensitivity : | 0.036 ng/mL |
| Assay Range : | 0.313 - 20 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Human Milk) |
| Applications : | ELISA |
Catalog #:
ARY019
Contains 4 membranes - each spotted in duplicate with 38 different kidney biomarker antibodies
WB, Simple Western, Flow, IHC, IP, CyTOF-ready, ICC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Simple Western, Western Blot |
Catalog #:
11302-ER
BA
HEK293 Expressed
| Source : | HEK293 |
| Accession # : | CAA25240.1 |
| Applications : | Bioactivity |
Catalog #:
ARY012
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
Catalog #:
MAB10951
Flow, CyTOF-ready
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #423103 |
| Applications : | CyTOF-ready, Flow Cytometry |
Catalog #:
FAB9577P
Flow
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | Flow Cytometry |
Catalog #:
7258
Potent EGFR PROTAC®
| Alternate Names : | Iressa-based PROTAC 3 |
| Chemical Name : | (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
7261
Selective EGFR PROTAC®
| Chemical Name : | (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
ELISA
| Applications : | ELISA |
Highly potent EGFR-kinase inhibitor
| Alternate Names : | Tyrphostin AG 1478 |
| Chemical Name : | N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride |
| Purity : | ≥98% (HPLC) |
WB, Simple Western, IHC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Simple Western, Western Blot |
WB
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #102618 |
| Applications : | Western Blot |
Catalog #:
10405-ER
BA
| Source : | CHO |
| Accession # : | XP_005549616.1 |
| Applications : | Bioactivity |
