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EGFR Products
EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.
111 results for "EGFR" in Products
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EGFR Products
EGFR (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGFR homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.
111 results for "EGFR" in Products
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Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Simple Western, Western Blot |
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
Orally active, selective EGFR inhibitor
| Alternate Names : | Gefitinib, ZD 1839 |
| Chemical Name : | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine |
| Purity : | ≥98% (HPLC) |
Analyzed by SEC-MALS
| Source : | NS0 |
| Accession # : | CAA25240.1 |
| Applications : | Binding Activity |
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
| Source : | NS0 |
| Accession # : | CAA25240 |
| Applications : | Bioactivity |
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
| Alternate Names : | BIBW2992 |
| Chemical Name : | (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate |
| Purity : | ≥98% (HPLC) |
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
| Sensitivity : | 0.036 ng/mL |
| Assay Range : | 0.313 - 20 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Human Milk) |
| Applications : | ELISA |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | CyTOF-ready, Flow Cytometry |
HEK293 Expressed
| Source : | HEK293 |
| Accession # : | CAA25240.1 |
| Applications : | Bioactivity |
Biotinylated
| Source : | HEK293 |
| Accession # : | CAA25240.1 |
| Applications : | Bioactivity |
Potent EGFR PROTAC®; also degrades HER2
| Chemical Name : | (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Potent, reversible EGFR tyrosine kinase inhibitor
| Chemical Name : | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
| Purity : | ≥98% (HPLC) |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | Flow Cytometry, Immunocytochemistry/Immunofluorescence |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #102618 |
| Applications : | Western Blot |
Iressa synthesized to Ancillary Material Grade
| Chemical Name : | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine |
| Purity : | ≥98% |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu1 |
| Applications : | Flow Cytometry |
| Source : | NS0 |
| Accession # : | CAA25240.1 |
| Applications : | Bioactivity |
