DNMT1 Products
DNMT1 (DNA methyltransferase 1; also MCMT and CXXC-type Zn finger protein 9) is a 190 kDa member of the C5-methyltransferase family of enzymes. DNMT1 is ubiquitous in expression, and appears during the S-phase of the cell cycle. DNMT1 catalyzes the attachment of a methyl group to the C5 position of CpG cytosines using AdoMet/adenosylmethionine as a co factor. This acts to silence select genes during X chromosome inactivation and tumorigenesis. Human DNMT1 is 1616 amino acids (aa) in length. DNMT1 contains an N-terminal regulatory, homodimerization and target recognition region (aa 1-1100), a Gly-Lys linker segment (aa 1109-1120) and a catalytic domain (aa 1121-1616). DNMT1 is acetylated, phosphorylated, and SUMOylated. There are multiple splice variants of DNMT1. There is a deletion of aa 1-336, alternative start sites at Met122 and 62 aa upstream of the standard start site, and a 17 aa substitution for Pro149. Over aa 1381-1587, human DNMT1 shares 87% aa identity with mouse DNMT1.
6 results for "DNMT1" in Products
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DNMT1 Products
DNMT1 (DNA methyltransferase 1; also MCMT and CXXC-type Zn finger protein 9) is a 190 kDa member of the C5-methyltransferase family of enzymes. DNMT1 is ubiquitous in expression, and appears during the S-phase of the cell cycle. DNMT1 catalyzes the attachment of a methyl group to the C5 position of CpG cytosines using AdoMet/adenosylmethionine as a co factor. This acts to silence select genes during X chromosome inactivation and tumorigenesis. Human DNMT1 is 1616 amino acids (aa) in length. DNMT1 contains an N-terminal regulatory, homodimerization and target recognition region (aa 1-1100), a Gly-Lys linker segment (aa 1109-1120) and a catalytic domain (aa 1121-1616). DNMT1 is acetylated, phosphorylated, and SUMOylated. There are multiple splice variants of DNMT1. There is a deletion of aa 1-336, alternative start sites at Met122 and 62 aa upstream of the standard start site, and a 17 aa substitution for Pro149. Over aa 1381-1587, human DNMT1 shares 87% aa identity with mouse DNMT1.
6 results for "DNMT1" in Products
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Immunocytochemistry/Immunofluorescence, Knockout Validated, Western Blot |
DNA methyltransferase inhibitor
Alternate Names : | 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC 127716 |
Chemical Name : | 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
Purity : | ≥99% (HPLC) |
DNA methyltransferase inhibitor
Chemical Name : | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one |
Purity : | ≥98% (HPLC) |
DNA methyltransferase and cytidine deaminase inhibitor
Alternate Names : | NSC 309132 |
Chemical Name : | 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone |
Purity : | ≥99% (HPLC) |
Non-nucleoside DNA methyltransferase inhibitor
Chemical Name : | N-Phthalyl-L-tryptophan |
Purity : | ≥99% (HPLC) |
DNA methyltransferase inhibitor
Chemical Name : | N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide |
Purity : | ≥99% (HPLC) |