9 results for "Deubiquitinating Enzyme Inhibitors Small Molecules and Peptides" in Products
Deubiquitinating Enzyme Inhibitors: Small Molecules and Peptides
Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins.
USPs are the largest and best characterized of the DUB family. There are 63 putative human USP genes, and the proteins they encode are normally between 60 and 300 kDa in size. USPs cleave the isopeptide bond at the C-terminus of ubiquitin, preventing ...
Selective USP25 and USP28 inhibitor
| Chemical Name: | 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol |
| Purity: | ≥98% (HPLC) |
Selective USP7 inhibitor
| Chemical Name: | 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| Purity: | ≥98% (HPLC) |
Broad spectrum DUB inhibitor
| Chemical Name: | 2,6-Diamino-3,5-dithiocyanopyridine |
| Purity: | ≥98% (HPLC) |
USP7 inhibitor
| Chemical Name: | 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone |
| Purity: | ≥98% (HPLC) |
Selective USP30 inhibitor
| Chemical Name: | N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective USP1-UAF1 allosteric inhibitor
| Chemical Name: | 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
USP10 and USP13 inhibitor; inhibits autophagy
| Chemical Name: | 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective inhibitor of USP21; also NF-κB activator
| Chemical Name: | N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective USP1 allosteric inhibitor
| Alternate Names: | Ubiquitin-specific Protease 1 Inhibitor 1,USP1-IN-1,USP1 Inhibitor 1,RO7623066 |
| Chemical Name: | 6-(4-Cyclopropyl-6-methoxypyrimidin-5-yl)-1-(4-(1-isopropyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidine |
| Purity: | ≥98% (HPLC) |
