P 22077

Tocris Bioscience, part of Bio-Techne | Catalog # 4485

USP7 inhibitor
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Key Product Details

Description

USP7 inhibitor

View all Deubiquitinating Enzyme Inhibitors »

Product Description

P 22077 is an inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

Product Specifications

Molecular Weight

315.32

Formula

C12H7F2NO3S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone

CAS Number

1247819-59-5

PubChem ID

46931953

InChI Key

RMAMGGNACJHXHO-UHFFFAOYSA-N

SMILES

CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.53 100

Preparing Stock Solutions for P 22077

The following data is based on the product molecular weight 315.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Product Documents for P 22077

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for P 22077

For research use only

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