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8 results for "APP Small Molecules and Peptides" in Products

APP: Small Molecules and Peptides

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

Predominant amyloid β-protein fragment

Purity: ≥95% (HPLC)
Predominant amyloid β-protein fragment

Amyloid β-protein fragment

Purity: ≥95% (HPLC)
Amyloid β-protein fragment

STAT3 activator; also protects against β-amyloid neurotoxicity

Purity: ≥95% (HPLC)
STAT3 activator; also protects against β-amyloid neurotoxicity

Potent and selective ERβ agonist; neuroprotective

Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Purity: ≥98% (HPLC)
Potent and selective ERβ agonist; neuroprotective

Antiallergic; inhibits inflammatory mediator release from mast cells

Chemical Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Antiallergic; inhibits inflammatory mediator release from mast cells

β-secretase (BACE) inhibitor; inhibits amyloid assembly

Alternate Names: Epigallocatechin gallate
Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Purity: ≥98% (HPLC)
β-secretase (BACE) inhibitor; inhibits amyloid assembly

Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels

Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels

Inhibitor of Aβ42 fibril formation

Chemical Name: 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
Purity: ≥98% (HPLC)
Inhibitor of Aβ42 fibril formation
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