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63 results for "5-HT7" in Products

5-HT7 Products

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. This isoform (A) is the predominant isoform in spleen, caudate and hippocampus. 5-HT7 isoform B is expressed at lower levels. 5-HT7 belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Pharmacological and genetic tools targeting 5-HT7 in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS).

5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7

Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

Endogenous 5-HT receptor agonist

Potent and selective 5-HT7 antagonist; brain penetrant

Potent 5-HT7 agonist

High affinity and selective 5-HT7 antagonist; orally bioavailable

Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

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