5-Carboxamidotryptamine maleate

Name: 5-Carboxamidotryptamine maleate
Brand: Tocris Bioscience
SKU: 0458
Price: 246 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0458

Citations (14)

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Key Product Details

Description:	5-HT₁ agonist; also has high affinity for 5-ht_5a and 5-HT₇
Alternative Names:	AH-21467, 5-CT
Purity:	≥99% (HPLC)
Molecular Weight:	319.32

View Full Technical Details for 5-Carboxamidotryptamine maleate

Biological Activity for 5-Carboxamidotryptamine maleate

5-Carboxamidotryptamine maleate is a 5-HT₁ agonist with high affinity at 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-ht₅ and 5-HT₇ receptors.

Technical Data for 5-Carboxamidotryptamine maleate

M. Wt	319.32
Formula	C₁₁H₁₃N₃O.C₄H₄O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	74885-72-6
PubChem ID	11709509
InChi Key	PZQZSWAOVAMBQM-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.NCCC1=CNC2=CC=C(C=C12)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5-Carboxamidotryptamine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	31.93	100

Preparing Stock Solutions for 5-Carboxamidotryptamine maleate

The following data is based on the product molecular weight 319.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.32 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for 5-Carboxamidotryptamine maleate

References are publications that support the biological activity of the product.

Wood Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor. Eur.J.Pharmacol. 2000 PMID: 10822046
Nowak [³H]-5-carboxamidotryptamine labels 5HT_1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 1993 PMID: 8401931
Beer An investigation of the 5-HT_1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatr. in the central nervous system of seven species. Eur.J.Pharmacol. 1992 PMID: 1325915
Zifa and Fillion 5-Hydroxytryptamine receptors. Pharmacol.Rev. 1992 PMID: 1359584

Citations for 5-Carboxamidotryptamine maleate (14)

Showing 1 - 10 of 14 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 5-Carboxamidotryptamine maleate include:

Bijata et al. (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep. 19:1767
PMID: 28564597
Sargin et al. (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife. 5:e21416
PMID: 27874831
Chan et al. (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog. 12:e1005651
PMID: 27187180
Montalbano et al. (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol. 10:e0140369
PMID: 26460748
Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One. 22:42
PMID: 26076928
Kim et al. (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron. 190:4795
PMID: 23554310
Gantz et al. (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol. 78:807
PMID: 23764286
Murray et al. (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 106:925
PMID: 21653728
Manzke et al. (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci. 364:2589
PMID: 19651659
Müller et al. (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One. 4:e6453
PMID: 19649285
Seeburg et al. (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci. 24:10950
PMID: 15574745
Maclean and Morecroft (2001) Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol. 134:614
PMID: 11588116
Morecroft et al. (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol. 128:730
PMID: 10516655
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

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Showing 1 - 10 of 14 citations Showing All

Product Documents for 5-Carboxamidotryptamine maleate

COA

Certificate of Analysis

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