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Key Product Details
| Description: | Non-selective mGlu antagonist |
| Chemical Name: | (RS)-α-Methyl-4-carboxyphenylglycine |
| Purity: | ≥99% (HPLC) |
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Showing 1-5 of 12 citations
Citations (12)
Citations are publications that use Bio-techne products. Selected citations for (RS)-MCPG include:
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Scholler
(2017)
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol.
13(4):372
PMID: 28135236 -
Tang et al.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
J Neurosci.
35:3016
PMID: 25698739 -
Oh et al.
(2013)
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Proc Natl Acad Sci U S A.
110:E305
PMID: 23269840 -
Zhang and Lisman
(2012)
Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
Cereb Cortex.
107:1058
PMID: 22114157 -
Tronson et al.
(2010)
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
J Neurosci.
68:1007
PMID: 21075228 -
Shankar et al.
(2008)
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Nat Med.
14:837
PMID: 18568035 -
Petzold et al.
(2008)
Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
Biol Psychiatry.
58:897
PMID: 18579080 -
Muddashetty et al.
(2007)
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.
J Neurosci.
27:5338
PMID: 17507556 -
Jan and Westbrook
(2007)
Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
J Neurosci.
27:132
PMID: 17202480 -
Takayasu et al.
(2006)
Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
J Neurophysiol.
26:6563
PMID: 16775144 -
Ohba et al.
(2005)
BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
Proc Natl Acad Sci U S A.
15:291
PMID: 15238431 -
Zhuo et al.
(1999)
On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.
Learn Mem.
5:467
PMID: 10489262
There are no citations that match your criteria.
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Suppression of mGluRs activated by glutamate application
Species: HumanCell Line/Tissue: Stem cell - derived neurons(RS)-MCPG was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate and glycine, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG works as expected, but takes quite a long time to dissolve for stock preparation.
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