(RS)-MCPG

Name: ( RS )-MCPG
Brand: Tocris Bioscience
SKU: 0336
Rating: 4 (1 reviews)

Catalog # 0336

Citations (12)

(1)

COA / SDS

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Key Product Details

Description:	Non-selective mGlu antagonist
Chemical Name:	(RS)-α-Methyl-4-carboxyphenylglycine
Purity:	≥99% (HPLC)
Molecular Weight:	209.2

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Biological Activity

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer and Sodium Salt also available.

Technical Data

M. Wt	209.2
Formula	C₁₀H₁₁NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	146669-29-6
PubChem ID	1222
InChi Key	DNCAZYRLRMTVSF-UHFFFAOYSA-N
Smiles	NC(C(O)=O)(C)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 209.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.78 mL	23.90 mL	47.80 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
10 mM	0.48 mL	2.39 mL	4.78 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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References

References are publications that support the biological activity of the product.

Joly Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 1995 PMID: 7751958
Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387
Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746

Citations for (<em>RS</em>)-MCPG (12)

Showing 1 - 10 of 12 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (RS)-MCPG include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Tang et al. (2015) Stimulation-evoked Ca²⁺ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 35:3016
PMID: 25698739
Oh et al. (2013) Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 110:E305
PMID: 23269840
Zhang and Lisman (2012) Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons. Cereb Cortex. 107:1058
PMID: 22114157
Tronson et al. (2010) Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. J Neurosci. 68:1007
PMID: 21075228
Shankar et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 14:837
PMID: 18568035
Petzold et al. (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Biol Psychiatry. 58:897
PMID: 18579080
Muddashetty et al. (2007) Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome. J Neurosci. 27:5338
PMID: 17507556
Jan and Westbrook (2007) Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb. J Neurosci. 27:132
PMID: 17202480
Takayasu et al. (2006) Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover. J Neurophysiol. 26:6563
PMID: 16775144
Ohba et al. (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A. 15:291
PMID: 15238431
Zhuo et al. (1999) On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus. Learn Mem. 5:467
PMID: 10489262

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Suppression of mGluRs activated by glutamate application

Name: Sergiy Sylantyev

Species: Human

Cell Line/Tissue: Stem cell - derived neurons

(RS)-MCPG was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate and glycine, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG works as expected, but takes quite a long time to dissolve for stock preparation.

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