Key Product Details
Description: | Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336) |
Chemical Name: | (S)-α-Methyl-4-carboxyphenylglycine |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 209.2 |
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Citations for (S)-MCPG (24)
Citations are publications that use Bio-Techne products. Selected citations for (S)-MCPG include:
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Gu et al.
(2015)
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
Nat Commun.
6:6789
PMID: 25858512 -
Szokol et al.
(2015)
Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Elife.
9:49
PMID: 25762896 -
Rosa et al.
(2015)
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
J Neurosci.
4
PMID: 26274565 -
Stephen et al.
(2015)
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Proc Natl Acad Sci U S A.
35:15996
PMID: 26631479 -
Nieus et al.
(2014)
Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
Front Cell Neurosci.
8:246
PMID: 25202237 -
Navarrete et al.
(2012)
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
PLoS Biol.
10:e1001259
PMID: 22347811 -
Akerboom et al.
(2012)
Optimization of a GCaMP calcium indicator for neural activity imaging.
J Neurosci.
32:13819
PMID: 23035093 -
Platt et al.
(2012)
Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
PLoS One.
7:e36397
PMID: 22570709 -
Ali
(2011)
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
J Neurophysiol.
105:1051
PMID: 21123660 -
Shinoda et al.
(2010)
Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons.
PLoS One.
5:e10390
PMID: 20436928 -
Reissner et al.
(2010)
A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
J Neurosci.
30:8797
PMID: 20592201 -
Huang and Hsu
(2010)
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Cereb Cortex.
20:982
PMID: 19666830 -
Bagayogo and Dreyfus
(2009)
Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
ASN Neuro.
1
PMID: 19570026 -
Fukunaga et al.
(2007)
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Br J Pharmacol.
151:870
PMID: 17502847 -
Bender et al.
(2006)
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J Neurosci.
26:4166
PMID: 16624937 -
Melyan et al.
(2004)
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
J Neurosci.
24:4530
PMID: 15140923 -
Melis et al.
(2004)
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
J Neurosci.
24:10707
PMID: 15564588 -
Kumar and Foster
(2004)
Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
J Neurophysiol.
91:2437
PMID: 14762159 -
Paladini et al.
(2003)
DA controls the firing pattern of DA neurons via a network feedback mechanism.
Nat Neurosci.
100:2866
PMID: 12604788 -
Matthies et al.
(2000)
Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
Learn Mem.
7:227
PMID: 10940323 -
Vogt and Nicoll
(1999)
Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
Proc Natl Acad Sci U S A.
96:1118
PMID: 9927703 -
Dunaevsky et al.
(1999)
Developmental regulation of spine motility in the mammalian central nervous system.
Proc Natl Acad Sci U S A.
96:13438
PMID: 10557339 -
Min et al.
(1999)
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Proc Natl Acad Sci U S A.
96:9932
PMID: 10449797 -
Colwell et al.
(1996)
Regulation of N-MthD.-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Front Cell Neurosci.
93:1200
PMID: 8577740
There are no citations that match your criteria.
Customer Reviews for (S)-MCPG (1)
Customer Images
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Species: RatAssay Type: In VitroCell Line/Tissue: HippocampusWhen mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.
There are no reviews that match your criteria.