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Group I mGluR Antagonists Small Molecule

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Key Product Details

Description: Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
Chemical Name: (S)-α-Methyl-4-carboxyphenylglycine
Purity: ≥99% (HPLC)

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  • (S)-MCPG as a blocker of mGluR action
    Name: Sergiy Sylantyev | 26th May 2019
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    When mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.
    (S)-MCPG as a blocker of mGluR action Serum 0337

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