(S)-MCPG

Name: ( S )-MCPG
Brand: Tocris Bioscience
SKU: 0337
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0337

(1)

Citations (86)

COA / SDS

Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)

Key Product Details

Description:	Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
Chemical Name:	(S)-α-Methyl-4-carboxyphenylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	209.2

View Full Technical Details for (S)-MCPG

Technical Data
Citations / Reviews (1)

Biological Activity for (S)-MCPG

(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.

Racemate also available.

Technical Data for (S)-MCPG

M. Wt	209.2
Formula	C₁₀H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	150145-89-4
PubChem ID	446355
InChi Key	DNCAZYRLRMTVSF-JTQLQIEISA-N
Smiles	N[C@](C)(C(O)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-MCPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	20.92	100

Preparing Stock Solutions for (S)-MCPG

The following data is based on the product molecular weight 209.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.78 mL	23.90 mL	47.80 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
10 mM	0.48 mL	2.39 mL	4.78 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for (S)-MCPG

References are publications that support the biological activity of the product.

Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 1996 PMID: 8730745
Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387
Jane Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 1993 PMID: 7689710
Bordi Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology 1996 PMID: 9025103