(RS)-MCPG disodium salt

Name: ( RS )-MCPG disodium salt
Brand: Tocris Bioscience
SKU: 3696
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3696

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
Chemical Name:	(RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	253.16

View Full Technical Details for (RS)-MCPG disodium salt

Biological Activity for (RS)-MCPG disodium salt

(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer also available.

Technical Data for (RS)-MCPG disodium salt

M. Wt	253.16
Formula	C₁₀H₉NNa₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
PubChem ID	90488871
InChi Key	YGOTXTUQJLFNHB-UHFFFAOYSA-L
Smiles	[Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-MCPG disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25.32	100

Preparing Stock Solutions for (RS)-MCPG disodium salt

The following data is based on the product molecular weight 253.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.95 mL	19.75 mL	39.50 mL
5 mM	0.79 mL	3.95 mL	7.90 mL
10 mM	0.40 mL	1.98 mL	3.95 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (RS)-MCPG disodium salt

References are publications that support the biological activity of the product.

Joly Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 1995 PMID: 7751958
Collingridge and Watkins Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 1994 PMID: 7992387
Eaton Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect.

Citations for (RS)-MCPG disodium salt

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.

Customer Reviews for (RS)-MCPG disodium salt (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Suppression of mGluR action triggered by glutamate application

Name: Sergiy Sylantyev

Species: Human

Cell Line/Tissue: Stem cell - derived neurons

(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.

Reference

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for (RS)-MCPG disodium salt

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.