(+)-Bicuculline

Citations are publications that use Bio-Techne products. Selected citations for (+)-Bicuculline include:

• He et al. (2020) Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice Cell Rep. 33
  PMID: 33147466
• Rivell et al. (2019) Sonic hedgehog expression in the postnatal brain. Biol Open. 8
  PMID: 30837226
• Velden et al. (2019) Modulation of Functional Connectivity Between DA Neurons of the Rat Ventral Tegmental Area in vitro. Front Integr Neurosci. 13:20
  PMID: 31293395
• Wagner et al. (2019) Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep. 28:11
  PMID: 31269433
• Zhang et al. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation. Neuron. 98:918
  PMID: 29754751
• Morel et al. (2018) JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 38:3708
  PMID: 29540552
• McKay et al. (2018) The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 25:841
  PMID: 30355491
• Marinangeli et al. (2018) AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience. 9:1
  PMID: 30368077
• Montandon (2017) δ-subunit containing GABAA receptors modulate respiratory networks. Sci Rep. 7(1):18105
  PMID: 29273726
• Zhu et al. (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 8:1676
  PMID: 29162816
• Li et al. (2017) Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity. Cell. 168:86
  PMID: 27916275
• Leal et al. (2017) The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. Eneuro. 4
  PMID: 29255796
• Dinamarca et al. (2016) Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. Elife. 5
  PMID: 26977767
• Imlach et al. (2016) Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain Scientific Reports. 6:37104
  PMID: 27841371
• Acuña et al. (2016) Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. J Clin Invest. 126:2547
  PMID: 27270175
• Brown et al. (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem. 291:13926
  PMID: 27129275
• Datta et al. (2016) Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. 30:177
  PMID: 27497748
• Dubal et al. (2015) Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci. 35:2358
  PMID: 25673831
• Telese et al. (2015) LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron. 86:696
  PMID: 25892301
• Ciani et al. (2015) Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun. 6:8302
  PMID: 26400647
• Hengen et al. (2015) Daily isofl. exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs. PLoS One. 10:e0119351
  PMID: 25748028
• Wu et al. (2015) Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. J Biomed Sci. 22:94
  PMID: 26494028
• Morini et al. (2015) Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons. Stem Cell Res Ther. 6:166
  PMID: 26345473
• Pappas et al. (2015) Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons. Elife. 4:e08352
  PMID: 26052670
• Campbell et al. (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Front Cell Neurosci. 8:425
  PMID: 25565960
• Curcio et al. (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis. 6:e1645
  PMID: 25675305
• Huckstepp et al. (2015) Role of parafacial nuclei in control of breathing in adult rats. J Neurosci. 35:1052
  PMID: 25609622
• Puranam et al. (2015) Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci. 35:8866
  PMID: 26063919
• Baquero et al. (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. J Neurosci. 35:8558
  PMID: 26041922
• John et al. (2015) Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus. Brain Res. 1601:15
  PMID: 25553616
• Lee et al. (2015) N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. Mol Brain. 8:4
  PMID: 25599691
• Quintana et al. (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. J Physiol. 593:4373
  PMID: 26174503
• Zimmermann et al. (2015) Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3. Front Synaptic Neurosci. 7:16
  PMID: 26441632
• Ding et al. (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. J Psychopharmacol. 29:725
  PMID: 25922425
• Kangarlu-Haghighi et al. (2015) The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA. EXCLI J. 14:613
  PMID: 26648818
• Robinson et al. (2015) Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Front Cell Neurosci. 9:404
  PMID: 26500501
• Bernard and Zhang (2015) MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS One. 10:e0124816
  PMID: 25932647
• Curtin and Preuss (2015) Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network. Front Neural Circuits. 9:12
  PMID: 25852486
• Scudder and Patrick (2015) Synaptic structure and function are altered by the neddylation inhibitor MLN4924. Mol Cell Neurosci. 65:52
  PMID: 25701678
• Accardi et al. (2015) α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells. J Neurosci. 35:9676
  PMID: 26134650
• Gaffaney et al. (2014) Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell. 25:481
  PMID: 24356452
• Lee et al. (2014) Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase. Philos Trans R Soc Lond B Biol Sci. 369:20130158
  PMID: 24298159
• Bemben et al. (2014) CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci. 17:56
  PMID: 24336150
• Weston et al. (2014) Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci. 7:1
  PMID: 24574959
• Suzuki et al. (2014) Imaging intraorganellar Ca²⁺ at subcellular resolution using CEPIA. Nat Commun. 5:4153
  PMID: 24923787
• Oostland et al. (2014) Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice. Cerebellum. 13:491
  PMID: 24788088
• Chen et al. (2014) Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Front Behav Neurosci. 8:219
  PMID: 24987341
• Accardi et al. (2014) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun. 5:3168
  PMID: 24430741
• Verstegen et al. (2014) Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J Neurosci. 34:7266
  PMID: 24849359
• Korb et al. (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 16:874
  PMID: 23749147
• Zemoura et al. (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem. 288:34897
  PMID: 24114844
• Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol. 17:553
  PMID: 24381506
• Velmans et al. (2013) Plasticity-related gene 3 promotes neurite shaft protrusion. BMC Neurosci. 14:36
  PMID: 23506325
• Berlinguer-Palmini et al. (2013) GPR35 activation reduces Ca²⁺ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One. 8:e82180
  PMID: 24312407
• Medrihan et al. (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nat Commun. 4:1512
  PMID: 23443540
• Chen et al. (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 33:8336
  PMID: 23658173
• Gao and Derbenev (2013) Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla. J Neurophysiol. 110:2637
  PMID: 24027107
• Hou and Yu (2013) Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4. J Biol Chem. 288:2501
  PMID: 23233668
• Deeb et al. (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states. Eur J Neurosci. 38:2453
  PMID: 23627375
• Koeglsperger et al. (2013) Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. 61:985
  PMID: 23536313
• Daftary et al. (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. 224:125
  PMID: 22917617
• Kaufman et al. (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. J Neurosci. 32:3992
  PMID: 22442066
• Yamamoto et al. (2012) Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation. J Neurosci. 32:14254
  PMID: 23055494
• Dagostin et al. (2012) Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation. J Comp Physiol A Neuroethol Sens Neural Behav Phys. 198:705
  PMID: 22752655
• Yao et al. (2012) Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nat Neurosci. 15:243
  PMID: 22197832
• Weston et al. (2012) Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci. 32:11441
  PMID: 22895726
• Zhu et al. (2011) Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex. PLoS One. 6:e16673
  PMID: 21304962
• Uschakov et al. (2011) Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons. PLoS One. 6:e16672
  PMID: 21347440
• Porcher et al. (2011) Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. J Biol Chem. 286:21667
  PMID: 21474450
• Mou et al. (2011) Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathways. Neuroscience. 176:72
  PMID: 21195749
• Yue et al. (2011) Potentiating action of PropF. at GABAA receptors of retinal bipolar cells. Invest Ophthalmol Vis Sci. 52:2497
  PMID: 21071744
• Gangadharan et al. (2011) Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest. 121:1608
  PMID: 21383497
• Smejkalova and Woolley (2010) OE acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism. J Neurosci. 30:16137
  PMID: 21123560
• Acuna-Goycolea et al. (2010) Cannabinoids excite circadian clock neurons. J Neurosci. 30:10061
  PMID: 20668190
• Mah et al. (2010) Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation. J Neurosci. 30:5559
  PMID: 20410109
• Yeh et al. (2010) SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog. 6:e1001207
  PMID: 21124874
• Thyagarajan and Ting (2010) Imaging activity-dependent regulation of neurexin-neuroligin interactions using trans-synaptic enzymatic biotinylation. Cell. 143:456
  PMID: 20933261
• Zhao et al. (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol. 588:2605
  PMID: 20519319
• Han et al. (2010) Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction. Am J Physiol Regul Integr Comp Physiol. 299:R129
  PMID: 20164200
• Lin et al. (2009) Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J. 96:1803
  PMID: 19254539
• Kuroyanagi et al. (2009) Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission. Proc Natl Acad Sci U S A. 106:4912
  PMID: 19258455
• Yeo et al. (2009) Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. J Neurosci. 29:14652
  PMID: 19923298
• Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron. 63:482
  PMID: 19709630
• Zhang et al. (2009) Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res. 1247:196
  PMID: 18992727
• Andäng et al. (2008) Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature. 451:460
  PMID: 18185516
• Hong et al. (2008) Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice. J Neurosci. 28:13003
  PMID: 19036993
• Soriano et al. (2008) Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci. 28:10696
  PMID: 18923045
• Zhang et al. (2008) Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp Neurol. 212:44
  PMID: 18495119
• Gil et al. (2008) Transient allodynia pain models in mice for early assessment of analgesic activity. Br J Pharmacol. 153:769
  PMID: 17700719
• Brager and Johnston (2007) Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 27:13926
  PMID: 18094230
• Riccio et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell. 21:283
  PMID: 16427017
• Surges et al. (2006) Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci. 24:94
  PMID: 16882011
• Berghuis et al. (2005) Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A. 102:19115
  PMID: 16357196
• Alldred et al. (2005) Distinct γ2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin. J Neurosci. 25:594
  PMID: 15659595
• Lenz and Avruch (2005) Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem. 280:38121
  PMID: 16183639
• Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain. 1:2
  PMID: 15813991
• Huang et al. (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 24:4551
  PMID: 15140926
• Rouaud and Billard (2003) D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol. 140:1051
  PMID: 14530208
• Krucker et al. (2000) Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci U S A. 97:6856
  PMID: 10823894

There are no citations that match your criteria.

Customer Images

• 
• (1)

• Use of BIC as a selective GABA-A receptor antagonist

  Name: Anonymous
  Species: Rat
  Assay Type: In Vitro
  Cell Line/Tissue: Hippocampus
  We have used (+)-Bicuculline (BIC) as a control tool to make sure that only GABA-A receptors are active under perfusion with given set of neuroreceptor antagonists.Being applied at membrane patches excised from cerebellar granule cell, 10 microM GABA triggered clear single-channel openings of GABA-A receptors. However, 100 microM BIC added together with GABA completely suppressed all single-channel activity, thus proving absence of other receptor types.
  PMID: 23447601
  

There are no reviews that match your criteria.