(+)-Bicuculline

Name: (+)-Bicuculline
Brand: Tocris Bioscience
SKU: 0130
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0130

(1)

Citations (989)

COA / SDS

Potent GABAA antagonist

Key Product Details

Description:	Potent GABA_A antagonist
Chemical Name:	[R-(R,S)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	367.36

View Full Technical Details for (+)-Bicuculline

Technical Data
Citations / Reviews (1)

Biological Activity for (+)-Bicuculline

(+)-Bicuculline is a classical GABA_A antagonist.

Methoiodide Salt, Methobromide Salt and Methochloride Salt also available.

Technical Data for (+)-Bicuculline

M. Wt	367.36
Formula	C₂₀H₁₇NO₆
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	485-49-4
PubChem ID	10237
InChi Key	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Smiles	[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CCN2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Bicuculline

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.74	100

Preparing Stock Solutions for (+)-Bicuculline

The following data is based on the product molecular weight 367.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.61 mL	27.22 mL
5 mM	0.54 mL	2.72 mL	5.44 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

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Reconstitution Calculator

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References for (+)-Bicuculline

References are publications that support the biological activity of the product.

Sieghart Multiplicity of GABA_A-benzodiazepine receptors. TiPS 1989 PMID: 2559519
Olsen Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 1976 PMID: 1247886
Piredda Intracerebral site of convulsant action of bicuculline. Life Sci. 1985 PMID: 3982215
Curtis GABA, bicuculline and central inhibition. Nature 1970 PMID: 4393081