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(-)-Bicuculline methiodide

Tocris Bioscience a Bio-Techne Brand

GABA-A Receptor Antagonists Small Molecule
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Key Product Details

Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Purity: ≥99% (HPLC)
Molecular Weight: 509.3

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Citations for (-)-Bicuculline methiodide (51)

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Customer Reviews for (-)-Bicuculline methiodide (3)

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  • reliable product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    We increased synaptic activity using a standard pharmacological approach (20 μM bicuculline and 100 μM 4-AP.
    (-)-Bicuculline methiodide Serum 2503
  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    1mM Bicuculline
    (-)-Bicuculline methiodide Serum 2503
  • Bicuculline methiodide as a test tool of GABA-A receptor pharmacological properties
    Name: Sergiy Sylantyev
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human embryo kidney cells
    Bicuculline methiodide (Bic) was used to test GABA-A receptors pharmacological properties after expression in pre-transfected HEK cells. 100 microM of Bic fullu suppressed chloride current generated by application of 50 microM GABA at outside-out membrane patch. Figure: black trace - application of GABA, grey trace - application of GABA+Bic.
    (-)-Bicuculline methiodide Serum 2503

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Product Documents for (-)-Bicuculline methiodide

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