(-)-Bicuculline methiodide
Tocris Bioscience, part of Bio-Techne | Catalog # 2503
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Key Product Details
Description
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Product Description
(-)-Bicuculline methiodide is a methiodide form of classical GABAA receptor antagonist (+)-bicuculline. More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.Methobromide Salt and Methochloride Salt also available.
Product Specifications
Molecular Weight
509.30
Formula
C21H20INO6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
CAS Number
40709-69-1
PubChem ID
104871
InChI Key
HKJKCPKPSSVUHY-GRTNUQQKSA-M
SMILES
[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[I-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.19 | 20 | |
| DMSO | 25.46 | 50 |
Preparing Stock Solutions
for (-)-Bicuculline methiodide
The following data is based on the product molecular weight 509.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.93 mL | 19.63 mL | 39.27 mL |
| 2.5 mM | 0.79 mL | 3.93 mL | 7.85 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seutin and Johnson Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 1999 PMID: 10390643
- Kurt Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex. Hear.Res. 2006 PMID: 16442250
- Olsen Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 1976 PMID: 1247886
Product Specific Notices for (-)-Bicuculline methiodide
For research use only
Loading...
Loading...
Loading...