(-)-Bicuculline methochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130) |
Chemical Name: | [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 417.85 |
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Citations for (-)-Bicuculline methochloride (23)
Citations are publications that use Bio-Techne products. Selected citations for (-)-Bicuculline methochloride include:
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Pati et al.
(2020)
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
ELife.
9
PMID: 32955432 -
Wagner et al.
(2019)
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Cell Rep.
28:11
PMID: 31269433 -
Dong et al.
(2018)
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Cell Rep.
24:284
PMID: 29996090 -
Tushev et al.
(2018)
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Neuron.
98:495
PMID: 29656876 -
Lai et al.
(2017)
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Neuron.
95:591
PMID: 28772123 -
Sigler et al.
(2017)
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Neuron.
94:304
PMID: 28426965 -
Dilger et al.
(2015)
Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
J Neurosci.
35:3652
PMID: 25716863 -
Choe et al.
(2015)
High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Neuron.
85:549
PMID: 25619659 -
Angelantonio et al.
(2015)
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
Front Cell Neurosci.
9:409
PMID: 26528137 -
Erkens et al.
(2015)
Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
Mol Brain.
8:1
PMID: 25571783 -
Jaiswal et al.
(2015)
Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
Front Cell Neurosci.
9:127
PMID: 25914623 -
Ly et al.
(2013)
T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.
Proc Natl Acad Sci U S A.
110:20302
PMID: 24277825 -
Rojas et al.
(2013)
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Mol Pharmacol.
83:106
PMID: 23066089 -
Nelson and Glitsch
(2012)
Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
J Biol Chem.
287:6326
PMID: 22207762 -
Dilger et al.
(2011)
Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
J Physiol.
589:919
PMID: 21173075 -
Couchman et al.
(2011)
Lateral superior olive function in congenital deafness.
Hear Res.
277:163
PMID: 21276842 -
Karst et al.
(2010)
Metaplasticity of amygdalar responses to the stress hormone corticosterone.
Proc Natl Acad Sci U S A.
107:14449
PMID: 20663957 -
Glitsch
(2010)
Activation of native TRPC3 cation channels by phospholipase D.
FASEB J.
24:318
PMID: 19741172 -
Woo et al.
(2007)
Neuregulin-1 enhances depolarization-induced GABA release.
Neuron.
54:599
PMID: 17521572 -
Nateri et al.
(2007)
ERK activation causes epilepsy by stimulating NMDA receptor activity.
EMBO J.
26:4891
PMID: 17972914 -
Kelm et al.
(2007)
Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
J Pharmacol Exp Ther.
323:356
PMID: 17652632 -
Shao et al.
(2003)
Spontaneous synaptic activity is primarily GABAergic in vestibular nucleus neurons of the chick embryo.
J Neurophysiol.
90:1182
PMID: 12904504 -
Vida and Frotscher
(2000)
A hippocampal interneuron associated with the mossy fiber system.
Proc Natl Acad Sci U S A.
97:1275
PMID: 10655521
There are no citations that match your criteria.
Customer Reviews for (-)-Bicuculline methochloride (1)
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Assay Type: In VitroCell Line/Tissue: Organotypic Hippocampus SlicesBath application of Bicuculline methochloride increased overall excitation of neurons in slice.
There are no reviews that match your criteria.