(-)-Bicuculline methobromide
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130) |
Chemical Name: | [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 462.3 |
Customers also Viewed
Customers also Purchased
Citations for (-)-Bicuculline methobromide (15)
Citations are publications that use Bio-Techne products. Selected citations for (-)-Bicuculline methobromide include:
-
Woo et al.
(2019)
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Exp Neurobiol.
28:30
PMID: 30853822 -
Nam et al.
(2019)
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Cell Rep.
28:1154
PMID: 31365861 -
Chen et al.
(2017)
Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.
Neuron.
96:1403
PMID: 29268099 -
Andrade-Talavera et al.
(2016)
Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.
Cereb Cortex.
26:3637
PMID: 27282393 -
Galván et al.
(2015)
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Neuroscience.
290:332
PMID: 25637803 -
Maccione et al.
(2014)
Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.
J Physiol.
592:1545
PMID: 24366261 -
Maguire et al.
(2014)
Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
Neuropsychopharmacology.
39:1232
PMID: 24264816 -
Johnson et al.
(2011)
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Neurosci Lett.
504:102
PMID: 21945652 -
Peng et al.
(2010)
Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
J Neurosci.
30:16220
PMID: 21123568 -
Galván et al.
(2010)
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
J Neurosci.
30:2844
PMID: 20181582 -
Sipilä et al.
(2009)
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
J Neurosci.
29:6982
PMID: 19474325 -
Krook-Magnuson et al.
(2008)
Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
J Neurophysiol.
100:932
PMID: 18509076 -
Miyazato et al.
(2008)
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
J Urol.
179:1178
PMID: 18206170 -
Gascon et al.
(2006)
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
J Neurosci.
26:12956
PMID: 17167085 -
Huang and Hessler
Social modulation during songbird courtship potentiates midbrain DArgic neurons.
PLoS One.
3:e3281
PMID: 18827927
There are no citations that match your criteria.
Customer Reviews for (-)-Bicuculline methobromide (1)
Customer Images
-
Species: HumanAssay Type: In VitroCell Line/Tissue: HEK-293Apart of classical action at GABA-A receptors, bicuculline methobromide (BIC) can be used as a tool to reveal presence of alpha2 glycine receptor (GlyR) subunit.In our work we transfected HEK cells with alpha2 and beta GlyR subunits to obtain heteromeric GlyRs. Application of glycine triggered a clear receptors response, but subsequent addition of BIC decreased response amplitude by >95% (see image). This confirmed expression of alpha2 subunits and their incorporation into active GlyRs.
There are no reviews that match your criteria.