Skip to main content

(-)-Bicuculline methobromide

GABA-A Receptor Antagonists Small Molecule
Catalog #
Availability
Size / Price
Qty
Loading...
0109/50
0109/10

Key Product Details

Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
Purity: ≥98% (HPLC)
Molecular Weight: 462.3

Complete Your Research

Complete Your Experiment

Citations (15)

Showing  1 - 10 of 15 citations Showing All
Search Title:

Citations are publications that use Bio-Techne products. Selected citations for (-)-Bicuculline methobromide include:

There are no citations that match your criteria.

Showing  1 - 10 of 15 citations Showing All

Customer Reviews (1)

5 out of 5
1 customer rating
5 stars
100%
4 stars
0%
3 stars
0%
2 stars
0%
1 star
0%

Customer Images


Showing  1 - 1 of 1 review Showing All
Filter By:
  • Bicuculline as an antagonist of alpha2 glycine receptor
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK-293
    Apart of classical action at GABA-A receptors, bicuculline methobromide (BIC) can be used as a tool to reveal presence of alpha2 glycine receptor (GlyR) subunit.In our work we transfected HEK cells with alpha2 and beta GlyR subunits to obtain heteromeric GlyRs. Application of glycine triggered a clear receptors response, but subsequent addition of BIC decreased response amplitude by >95% (see image). This confirmed expression of alpha2 subunits and their incorporation into active GlyRs.
    (-)-Bicuculline methobromide Serum 0109

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.