(-)-Bicuculline methobromide

Name: (-)-Bicuculline methobromide
Brand: Tocris Bioscience
SKU: 0109
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0109

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Citations (107)

COA / SDS

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

Key Product Details

Description:	GABA_A antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Chemical Name:	[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
Purity:	≥98% (HPLC)
Molecular Weight:	462.3

View Full Technical Details for (-)-Bicuculline methobromide

Technical Data
Citations / Reviews (1)

Biological Activity for (-)-Bicuculline methobromide

(-)-Bicuculline methobromide is a methobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methochloride Salt also available.

Technical Data for (-)-Bicuculline methobromide

M. Wt	462.3
Formula	C₂₁H₂₀BrNO₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	66016-70-4
PubChem ID	6852386
InChi Key	BWXCECYGGMGBHD-GRTNUQQKSA-M
Smiles	[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Bicuculline methobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.11	50

Preparing Stock Solutions for (-)-Bicuculline methobromide

The following data is based on the product molecular weight 462.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.33 mL	21.63 mL	43.26 mL
2.5 mM	0.87 mL	4.33 mL	8.65 mL
5 mM	0.43 mL	2.16 mL	4.33 mL
25 mM	0.09 mL	0.43 mL	0.87 mL

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Reconstitution Calculator

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References for (-)-Bicuculline methobromide

References are publications that support the biological activity of the product.

Seutin and Johnson Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 1999 PMID: 10390643
Sperber Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 1987 PMID: 3440204
Bowery Characteristics of GABA_B receptor binding sites on rat whole brain synaptic membranes. Br.J.Pharmacol. 1983 PMID: 6297646