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(-)-Bicuculline methobromide

GABA-A Receptor Antagonists Small Molecule

Key Product Details

Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
Purity: ≥98% (HPLC)
Molecular Weight: 462.3

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Citations for (-)-Bicuculline methobromide (15)

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  • Bicuculline as an antagonist of alpha2 glycine receptor
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK-293
    Apart of classical action at GABA-A receptors, bicuculline methobromide (BIC) can be used as a tool to reveal presence of alpha2 glycine receptor (GlyR) subunit.In our work we transfected HEK cells with alpha2 and beta GlyR subunits to obtain heteromeric GlyRs. Application of glycine triggered a clear receptors response, but subsequent addition of BIC decreased response amplitude by >95% (see image). This confirmed expression of alpha2 subunits and their incorporation into active GlyRs.
    (-)-Bicuculline methobromide Serum 0109

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