PJ 34 hydrochloride

Name: PJ 34 hydrochloride
Brand: Tocris Bioscience
SKU: 3255

Tocris Bioscience a Bio-Techne Brand

Catalog # 3255

Citations (1)

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Key Product Details

Description:	Potent PARP inhibitor
Chemical Name:	N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	331.8

View Full Technical Details for PJ 34 hydrochloride

Biological Activity for PJ 34 hydrochloride

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC₅₀ = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC₅₀ values are 3.7 and 16 μM respectively).

Compound Libraries for PJ 34 hydrochloride

PJ 34 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for PJ 34 hydrochloride

M. Wt	331.8
Formula	C₁₇H₁₇N₃O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	344458-15-7
PubChem ID	16760621
InChi Key	RURAZZMDMNRXMI-UHFFFAOYSA-N
Smiles	Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PJ 34 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	33.18	100
	DMSO	33.18	100

Preparing Stock Solutions for PJ 34 hydrochloride

The following data is based on the product molecular weight 331.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for PJ 34 hydrochloride

References are publications that support the biological activity of the product.

Kim Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 2012 PMID: 22437413
Antolin Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 2012 PMID: 23025350
Gambi Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 2008 PMID: 18468580
Abdelkarim Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 2001 PMID: 11179503

Citations for PJ 34 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for PJ 34 hydrochloride include:

Kirby et al. (2012) Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68:115
PMID: 22297980

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