Human IL-18/IL-1F4 ELISA
R&D Systems, part of Bio-Techne | Catalog # 7620
Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
Key Product Details
Sample Type & Volume Required Per Well
Cell Culture Supernates (150 µL), Serum (30 µL), EDTA Plasma (30 µL), Urine (150 µL)
Sensitivity
12.5 pg/mL
Assay Range
25.6-1000 pg/mL
Product Specifications
Measurement
Quantitative ELISA
Detection Method
Colorimetric - 450nm (TMB)
Conjugate
HRP
Reactivity
Human
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules. < 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.
Preparation and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-18/IL-1F4
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
Long Name
Interleukin 18
Alternate Names
IGIF, IL-1F4, IL-1g, IL18
Gene Symbol
IL18
Additional IL-18/IL-1F4 Products
Product Documents for Human IL-18/IL-1F4 ELISA
Product Specific Notices for Human IL-18/IL-1F4 ELISA
For research use only
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