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IL-18/IL-1F4: Proteins and Enzymes

IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.

10 results for "IL-18/IL-1F4 Proteins and Enzymes" in Products

IL-18/IL-1F4: Proteins and Enzymes

IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.

10 results for "IL-18/IL-1F4 Proteins and Enzymes" in Products

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A New rh IL-18 is Now Available! Competitively priced; Higher purity; Lower endotoxin; Manufactured in-house!

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A New rm IL-18 is Now Available! Competitively priced; Enhanced stability; Lower endotoxin specification; Made in-house!

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A New rh IL-18 is Available! Competitively priced; Higher purity; Lower endotoxin specifications; Made in-house!

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A New rm IL-18 is Now Available! Competitively priced; Lower endotoxin specifications; Made in-house!

Catalog #: 5989-RM
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