TGF-beta Pan Specific Antibody
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Immunogen: | Recombinant human TGF‑ beta 1, porcine platelet-derived TGF‑ beta 1.2, porcine platelet-derived TGF‑ beta 2, and recombinant amphibian TGF‑ beta 5 |
Applications: | Block/Neutralize, Immunohistochemistry, Western Blot |
Label: | Unconjugated |
Source: | Polyclonal Rabbit IgG |
Specificity: |
Detects TGF-beta 1, TGF-beta 1.2, TGF-beta 2, TGF-beta 3, and TGF-beta 5 in direct ELISAs and Western blots. |
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Citations for TGF-beta Pan Specific Antibody (55)
Citations are publications that use Bio-Techne products. Selected citations for TGF-beta Pan Specific Antibody include:
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Species: Human
Sample Types: Whole Tissue
Applications: IHCNM Kamal et al. (2022), Expression of TGF-beta and MMP-2 in hereditary gingival fibromatosis epithelial cells. A possible contribution of the epithelium to its pathogenesis Journal of oral biology and craniofacial research, 12(5):617-622.
PMID: 35989975 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationA Shi et al. (2021), TGF-&beta loaded exosome enhances ischemic wound healing in vitro and in vivo Theranostics, 11(13):6616-6631.
PMID: 33995680 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationJ Gokavi et al. (2021), Inhibition of miR-155 Promotes TGF-beta Mediated Suppression of HIV Release in the Cervical Epithelial Cells Viruses, 13(11).
PMID: 34835072 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationL Panahipour et al. (2020), TGF-&beta in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis Int J Mol Sci, 21(22).
PMID: 33202935 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationYE Choi et al. (2020), Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging Int J Mol Sci, 21(22).
PMID: 33217999 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: NeutralizationR García-Roc et al. (2019), Cervical cancer cells produce TGF-?1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-?1 Cytokine, 118(0):71-79.
PMID: 30301599 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationL Ji et al. (2019), Roxatidine inhibits fibrosis by inhibiting NF?kappaB and MAPK signaling in macrophages sensing breast implant surface materials Mol Med Rep, 0(0).
PMID: 31746427 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotJ Zheng et al. (2018), DNA methylation affects metastasis of renal cancer and is associated with TGF-?/RUNX3 inhibition Cancer Cell Int., 18(0):56.
PMID: 29651226 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureM Hulsmans et al. (2018), Cardiac macrophages promote diastolic dysfunction J. Exp. Med., 0(0).
PMID: 29339450 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationN Selvamurug et al. (2017), Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-? Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation Stem Cells Int, 2017(0):2450327.
PMID: 28512472 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationJ Xiao et al. (2017), The IL-2/Anti-IL-2 Complex Attenuates Cardiac Ischaemia-Reperfusion Injury Through Expansion of Regulatory T Cells Cell. Physiol. Biochem., 44(5):1810-1827.
PMID: 29224017 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationR Rouf et al. (2017), Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice JCI Insight, 2(15).
PMID: 28768908 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationD Pozzer et al. (2017), Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover Sci Rep, 7(0):40993.
PMID: 28106121 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationOE Olsen et al. (2017), TGF-? contamination of purified recombinant GDF15 PLoS ONE, 12(11):e0187349.
PMID: 29161287 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationY Yang et al. (2017), ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury J. Neurosci., 0(0).
PMID: 28389473 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationX Chen et al. (2016), TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions PLoS ONE, 11(4):e0153811.
PMID: 27104863 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), MXRA5 is a TGF-?1-regulated human protein with anti-inflammatory and anti-fibrotic properties J Cell Mol Med, 0(0).
PMID: 27599751 -
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot(2016), Lymphatic vessels regulate immune microenvironments in human and murine melanoma J Clin Invest, 0(0).
PMID: 27525437 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationVeltmann M et al. (2016), Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS ONE, 11(1):e0147312.
PMID: 26800359 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAngelucci C et al. (2015), Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts. Br J Cancer, 112(10):1675-86.
PMID: 25880005 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationGonzalez-Valdes I et al. (2015), Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun, 6(0):6473.
PMID: 25751743 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationHou X et al. (2015), CD4(+)Foxp3(+) Tregs protect against innate immune cell-mediated fulminant hepatitis in mice. Mol Immunol, 63(2):420-7.
PMID: 25315497 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BlockingZhang P et al. (2015), Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment. Sci Rep, 5(0):8919.
PMID: 25747469 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationXu S et al. (2014), Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta. PLoS ONE, 9(3):e91709.
PMID: 24638085 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationBernard M et al. (2014), Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy, 10(12):2193-207.
PMID: 25495560 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZhu L et al. (2014), Platelets provoke distinct dynamics of immune responses by differentially regulating CD4+ T-cell proliferation. J Thromb Haemost, 12(7):1156-65.
PMID: 24833264 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationStahli A et al. (2014), Emdogain-regulated gene expression in palatal fibroblasts requires TGF-betaRI kinase signaling. PLoS ONE, 9(9):e105672.
PMID: 25197981 -
Species: Rat
Sample Types: Whole Cells
Applications: NeutralizationKang I et al. (2014), Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor beta (TGFbeta)-, epidermal growth factor (EGF)-, and nuclear factor kappaB (NFkappaB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion. J Biol Chem, 289(22):15393-404.
PMID: 24719328 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationKim M et al. (2013), IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. J Am Soc Nephrol, 24(10):1529-36.
PMID: 23833258 -
Species: Human
Sample Types: In Vivo
Applications: BioassayOlson B et al. (2012), Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. J Immunol, 189(12):5590-601.
PMID: 23152566 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationFoley J et al. (2012), Toll-like Receptor 2 (TLR2), Transforming Growth Factor-beta, Hyaluronan (HA), and Receptor for HA-mediated Motility (RHAMM) Are Required for Surfactant Protein A-stimulated Macrophage Chemotaxis. J Biol Chem, 287(44):37406-19.
PMID: 22948158 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationLauzier A et al. (2012), Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis. Arthritis Res. Ther., 14(4):R159.
PMID: 22762273 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationBlom L et al. (2011), IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS ONE, 6(7):e21695.
PMID: 21765905 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationMa W et al. (2011), Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J. Clin. Invest., 121(11):4548-66.
PMID: 22005303 -
Species: Mouse
Sample Types: Whole Cells
Applications: ICCYamazaki S et al. (2011), Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 147(5):1146-58.
PMID: 22118468 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationSuzuki K et al. (2010), The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity, 33(1):71-83.
PMID: 20643338 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationKing VL et al. (2009), Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation, 119(3):426-35.
PMID: 19139386 -
Species: Rat
Sample Types: Whole Cells
Applications: NeutralizationAkool el-S et al. (2008), Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J. Immunol., 181(4):2831-45.
PMID: 18684975 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationShintani Y et al. (2007), Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am. J. Respir. Cell Mol. Biol., 38(1):95-104.
PMID: 17673689 -
Species: Rat
Sample Types: Whole Cells
Applications: ICCBoerma M et al. (2007), Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Res., 67(19):9501-6.
PMID: 17909060 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationMcLennan SV et al. (2007), Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int., 72(4):481-8.
PMID: 17554258 -
Species: Rat
Sample Types: CSF
Applications: NeutralizationMatsumura S et al. (2007), Increase in transforming growth factor-beta in the brain during infection is related to fever, not depression of spontaneous motor activity. Neuroscience, 144(3):1133-40.
PMID: 17156928 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationAlcorn JF et al. (2007), Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am. J. Respir. Crit. Care Med., 176(10):974-82.
PMID: 17761617 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationCohn RD et al. (2007), Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat. Med., 13(2):204-10.
PMID: 17237794 -
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western BlotMesples B et al. (2005), Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice. Neurobiol. Dis., 18(1):193-205.
PMID: 15649710 -
Species: Mouse
Sample Types: Whole Cells
Applications: Electron MicroscopyWaghabi MC et al. (2005), Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion. Am. J. Pathol., 167(4):993-1003.
PMID: 16192635 -
Species: Mink
Sample Types: Whole Cells
Applications: NeutralizationZamiri P et al. (2005), Thrombospondin plays a vital role in the immune privilege of the eye. Invest. Ophthalmol. Vis. Sci., 46(3):908-19.
PMID: 15728547 -
Species: Rat
Sample Types: Whole Cells
Applications: NeutralizationAkool el-S et al. (2005), Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. J. Biol. Chem., 280(47):39403-16.
PMID: 16183640 -
Species: Bovine
Sample Types: Whole Cells
Applications: NeutralizationGilchrist RB et al. (2004), Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity. Biol. Reprod., 71(3):732-9.
PMID: 15128595 -
Species: Goat
Sample Types: Whole Tissue
Applications: IHC-PLeung KS et al. (2004), Effect of weightbearing on bone formation during distraction osteogenesis. Clin. Orthop. Relat. Res., 0(419):251-7.
PMID: 15021163 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationZheng SG et al. (2004), Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol., 172(9):5213-21.
PMID: 15100259 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: NeutralizationTorrealba JR et al. (2004), Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 172(9):5753-64.
PMID: 15100322 -
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-PInkinen K et al. (2003), Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue. Connect. Tissue Res., 44(1):19-29.
PMID: 12945801 -
Species: Mouse
Sample Types: Whole Cells
Applications: NeutralizationLiu BY et al. (2002), Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC. 141-147, 143(2):627-35.
PMID: 11796519 -
Species: Mouse
Sample Types: In Vivo
Applications: NeutralizationIbrahim M et al. (0), Naive CD4(+) T Cells Carrying a TLR2 Agonist Overcome TGF-beta-Mediated Tumor Immune Evasion. J Immuno200(2):847-856.
PMID: 29212908
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Customer Reviews for TGF-beta Pan Specific Antibody (3)
Customer Images
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Application: IHCSample Tested: mouse oral tissueSpecies: MouseVerified Customer | Posted 11/23/2020
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Application: FlowSample Tested: Blood mononuclear cells (PBMCs)Species: HumanVerified Customer | Posted 03/23/2018
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Application: B/NSample Tested: Peritoneal macrophagesSpecies: MouseVerified Customer | Posted 06/06/2017
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FAQs for TGF-beta Pan Specific Antibody
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Does TGF-beta Pan Specific Antibody, catalog # AB-100-NA, recognize active or latent TGF-beta (LAP)?
This antibody recognizes mature (active) TGF-beta. We have not tested for cross-reactivity to LAP (catalog # 246-LP) in our neutralization assay. Some cross-reactivity to latent TGF-beta may also be observed in western blot.