Mouse IGF-I/IGF-1 Biotinylated Antibody
Catalog # BAF791 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Summary for Mouse IGF-I/IGF-1 Biotinylated Antibody
Immunogen
Gly33-Ala102
Accession # Q8CAR0
Specificity
Clonality
Host
Isotype
Applications for Mouse IGF-I/IGF-1 Biotinylated Antibody
Western Blot
Sample: Recombinant Mouse IGF-I/IGF-1 (Catalog # 791-MG)
Mouse IGF-I/IGF-1 Sandwich Immunoassay
Reviewed Applications
Read 1 review rated 5 using BAF791 in the following applications:
Published Applications
Read 5 publications using BAF791 in the following applications:
Formulation, Preparation and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IGF-I/IGF-1
Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF‑II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10).
References
- Philippou, A. et al. (2007) In Vivo 21:45.
- Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873.
- Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
- Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
- Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
- Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
- Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
- Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
- LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
- Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
Long Name
Alternate Names
Gene Symbol
UniProt
Product Documents for Mouse IGF-I/IGF-1 Biotinylated Antibody
Product Specific Notices for Mouse IGF-I/IGF-1 Biotinylated Antibody
For research use only
Citations for Mouse IGF-I/IGF-1 Biotinylated Antibody (5)
Citations are publications that use Bio-Techne products. Selected citations for Mouse IGF-I/IGF-1 Biotinylated Antibody include:
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Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development (Detection)Fletcher L et al. (2013-12-21), Spatial distribution of insulin-like growth factor binding protein-2 following hypoxic-ischemic injury. BMC Neurosci, 2013-114(0):158.
PMID: 24359611 -
Species: Mouse
Sample Types: Serum
Applications: ELISA DevelopmentMehta HH et al. (2011-06-22), IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res., 2011-071(15):5154-63.
PMID: 21697285 -
Species: Mouse
Sample Types: Serum
Applications: ELISA DevelopmentYamada PM et al. (2010-10-06), Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology, 2010-1151(12):5741-50.
PMID: 20926583 -
Species: Mouse
Sample Types: Plasma
Applications: ELISA DevelopmentWang N et al. (2009-04-14), Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. Mol. Ther., 2009-017(7):1241-9.
PMID: 19367255 -
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA DevelopmentRaina K et al. (2007-11-15), Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res., 2007-167(22):11083-91.
PMID: 18006855
There are no citations that match your criteria.
Customer Reviews for Mouse IGF-I/IGF-1 Biotinylated Antibody (1)
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Application: ELISASample Tested: Adipocytes, Small intestine tissue, Serum, Adipose tissue, Large intestine and Liver tissueSpecies: Bacterial and MouseVerified Customer | Posted 02/22/2016Homemade ELISA, used R and D systems capture antibody and purified protein
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