Human NKG2D/CD314 Antibody
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity: | Human |
Immunogen: | BaF3 mouse pro-B cell line transfected with human NKG2D/CD314 |
Applications: | Block/Neutralize, CyTOF-ready, Flow Cytometry, Functional Assay, Western Blot |
Label: | Unconjugated |
Source: | Monoclonal Mouse IgG1 Clone # 149810 |
Specificity: |
Detects human NKG2D/CD314 in Western blots. |
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Citations for Human NKG2D/CD314 Antibody (82)
Citations are publications that use Bio-Techne products. Selected citations for Human NKG2D/CD314 Antibody include:
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Species: Human
Sample Types: Whole Cells
Applications: NeutralizationN Allende-Ve et al. (2022), Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1) Scientific Reports, 12(1):1341.
PMID: 35079096 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationHY Wu et al. (2022), Venetoclax enhances NK cell killing sensitivity of AML cells through the NKG2D/NKG2DL activation pathway International immunopharmacology, 104(0):108497.
PMID: 34999394 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationS Belkahla et al. (2022), The metabolism of cells regulates their sensitivity to NK cells depending on p53 status Scientific Reports, 12(1):3234.
PMID: 35217717 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryMC Puzzolo et al. (2022), Immunomodulatory Effects of IFNalpha on T and NK Cells in Chronic Myeloid Leukemia Patients in Deep Molecular Response Preparing for Treatment Discontinuation Journal of Clinical Medicine, 11(19).
PMID: 36233461 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationR Chimienti et al. (2022), Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for beta cell replacement Cell Reports, 40(13):111423.
PMID: 36170817 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryX Zhong et al. (2021), The diterpenoid adenanthin upregulates the expression of natural killer group 2D receptor ligands in hepatocellular carcinoma cells Molecular and cellular probes, 59(0):101759.
PMID: 34265372 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationE Seidel et al. (2021), The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing PloS Pathogens, 17(5):e1008807.
PMID: 33939764 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationS Petillo et al. (2021), Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition Cell Death Disease, 2021;12(9):836.
PMID: 34482362 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationD Westhoff S et al. (2021), The Epstein-Barr Virus Oncogene EBNA1 Suppresses Natural Killer Cell Responses and Apoptosis Early after Infection of Peripheral B Cells MBio, 0(0):e0224321.
PMID: 34781735 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationS Capellero et al. (2020), Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer Sci Rep, 10(1):6478.
PMID: 32296104 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: NeutralizationM Diab et al. (2020), Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D Viruses, 12(7).
PMID: 32698530 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryB Müller-Dur et al. (2019), CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Aging (Albany NY), 11(2):724-740.
PMID: 30686790 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationCF Amorim et al. (2019), The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers J Immunol Res, 2019(0):6574828.
PMID: 30944834 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationE Oh et al. (2019), Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect) Cancers (Basel), 11(7).
PMID: 31324057 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationA Gras Navar et al. (2019), Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival Cancers (Basel), 11(7).
PMID: 31319548 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryHG Wirsching et al. (2019), Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma JCI Insight, 4(13).
PMID: 31292299 -
Species: Human
Sample Types: Whole Cells
Applications: StimulationKM Wilton et al. (2019), NKG2D/DAP10 Signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity J. Cell. Sci., 0(0).
PMID: 31235500 -
Species: Human
Sample Types: Whole Cells
Applications: IHCDP Muñoz et al. (2019), Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 5(0).
PMID: 31184599 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationYS Lee et al. (2018), The combination of ionizing radiation and proteasomal inhibition by bortezomib enhances the expression of NKG2D ligands in multiple myeloma cells J. Radiat. Res., 0(0).
PMID: 29518205 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationYM Dai et al. (2018), EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances ??T cell-mediated cytotoxicity via TCR and NKG2D Immunology, 0(0).
PMID: 29512904 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS López-Cobo et al. (2018), Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors Oncoimmunology, 7(2):e1392426.
PMID: 29308322 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayO Matalon et al. (2018), Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1 EMBO J., 0(0).
PMID: 29449322 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationJ Prévost et al. (2018), Incomplete downregulation of CD4 expression affects HIV-1 Env conformation and ADCC responses J. Virol., 0(0).
PMID: 29669829 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationJRM Van Audena et al. (2017), Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells Oncotarget, 0(0).
PMID: 28615524 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationF Lin et al. (2017), Prognostic significance and functional implication of immune activating receptor NKG2D in gastric cancer Biochem. Biophys. Res. Commun., 0(0).
PMID: 28433635 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayH Jensen et al. (2017), EBI3 regulates the NK cell response to mouse cytomegalovirus infection Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28143936 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationY Charpak-Am et al. (2017), Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20 Sci Rep, 7(1):8661.
PMID: 28819195 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationS Santaguida et al. (2017), Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System Dev. Cell, 41(6):638-651.e5.
PMID: 28633018 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationZ Djaoud et al. (2017), Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells J. Exp. Med., 0(0).
PMID: 28468758 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayX Cai et al. (2017), Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells Neoplasia, 19(6):471-482.
PMID: 28499126 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationC Niu et al. (2017), Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and ?? T cell-mediated lysis in multiple myeloma Oncotarget, 8(4):5954-5964.
PMID: 27992381 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers Sci Rep, 6(0):39231.
PMID: 27995954 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationM Ke et al. (2016), SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice Oncotarget, 7(31):49509-49526.
PMID: 27385218 -
Species: Human
Sample Types: Whole Cells
Applications: Neutralization(2016), NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma Oncotarget, 0(0).
PMID: 27655680 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationFrishman-Levy L et al. (2015), Central nervous system acute lymphoblastic leukemia: role of natural killer cells. Blood, 125(22):3420-31.
PMID: 25896649 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryKruse V et al. (2015), Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. PLoS ONE, 10(5):e0125544.
PMID: 25950680 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationGiannattasio A et al. (2015), Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids. BMC Cancer, 15(0):351.
PMID: 25933805 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAwad A et al. (2014), Natural killer cells induce eosinophil activation and apoptosis. PLoS ONE, 9(4):e94492.
PMID: 24727794 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationSerrano-Pertierra E et al. (2014), L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. J Leukoc Biol, 96(3):437-45.
PMID: 24803550 -
Species: Human
Sample Types: Whole Cells
Applications: ICCMolfetta R et al. (2014), c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells. Eur J Immunol, 44(9):2761-70.
PMID: 24846123 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationSangiolo et al. (2014), Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas. Cancer Res, 74(1):119-29.
PMID: 24356422 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryKarimi M et al. (2014), A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function. J Immunol, 193(6):2764-71.
PMID: 25092887 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCelis-Gutierrez J et al. (2014), Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J, 33(17):1928-40.
PMID: 24963146 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationLim S et al. (2013), Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res, 73(8):2598-607.
PMID: 23580577 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayHam et al. (2013), Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol, 190(7):3661-9.
PMID: 23455509 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationHosomi S et al. (2013), CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol, 43(9):2473-83.
PMID: 23696226 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWindheim et al. (2013), A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions. Proc Natl Acad Sci U S A, 110(50):E4884-93.
PMID: 24218549 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationHo et al. (2013), The road to memory: an early rest for the long journey. J Immunol, 191(11):5603-14.
PMID: 24184558 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDi Carlo E et al. (2013), Mechanisms of the antitumor activity of human Vgamma9Vdelta2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma. Mol Ther, 21(5):1034-43.
PMID: 23481325 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationLeung W et al. (2013), Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. J Exp Med, 210(12):2675-92.
PMID: 24190430 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationGlassner A et al. (2012), NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. Lab. Invest., 92(7):967-77.
PMID: 22449797 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayNielsen N et al. (2012), Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS ONE, 7(2):e31959.
PMID: 22384114 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryTsukerman P et al. (2012), MiR-10b Downregulates the Stress-Induced Cell Surface Molecule MICB, a Critical Ligand for Cancer Cell Recognition by Natural Killer Cells. Cancer Res, 72(21):5463-72.
PMID: 22915757 -
Species: Human
Sample Types: Whole Cells
Applications: Functional Assay(2012), Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur J Immunol, 42(8):2142-51.
PMID: 22585739 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationAndresen L et al. (2012), 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J. Immunol., 188(4):1847-55.
PMID: 22227571 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBrown A et al. (2012), Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins. Blood, 120(18):3729-40.
PMID: 22966166 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryHeinemann A et al. (2012), Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res., 72(2):460-71.
PMID: 22102694 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationMorandi F et al. (2012), Human TCR gamma delta+ T cells represent a novel target for IL-27 activity. Eur. J. Immunol., 42(6):1547-52.
PMID: 22678908 -
Species: Human
Sample Types: Whole Cells
Applications: BlockingDonia M et al. (2012), Analysis of Vdelta1 T cells in clinical grade melanoma-infiltrating lymphocytes. Oncoimmunology, 1(8):1297-1304.
PMID: 23243593 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationInoue T et al. (2011), Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins. Int. J. Oncol., 38(5):1299-306.
PMID: 21373756 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayAngelini DF et al. (2011), NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. J. Leukoc. Biol., 89(1):75-84.
PMID: 20952657 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryArdolino M et al. (2011), DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction. Blood, 117(18):4778-86.
PMID: 21406724 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayQin H et al. (2011), Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling. Diabetes, 60(3):857-66.
PMID: 21270236 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryCabezon R et al. (2011), Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol. Lett., 134(2):167-73.
PMID: 20933012 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationManiar A et al. (2010), Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood, 116(10):1726-33.
PMID: 20519625 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationCho D et al. (2010), Cytotoxicity of activated natural killer cells against pediatric solid tumors. Clin. Cancer Res., 16(15):3901-9.
PMID: 20542985 -
Species: Human
Sample Types: Whole Cells
Applications: BlockingSchwinn N et al. (2009), Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. Int. J. Cancer, 124(7):1594-604.
PMID: 19089914 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayPurdy AK et al. (2009), SHP-2 expression negatively regulates NK cell function. J. Immunol., 183(11):7234-43.
PMID: 19915046 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationMarkel G et al. (2009), Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells. PLoS ONE, 4(5):e5597.
PMID: 19440333 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayCerboni C et al. (2009), Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood, 113(13):2955-64.
PMID: 19124832 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationTang KF et al. (2008), Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine. Biochem. Biophys. Res. Commun., 370(4):578-83.
PMID: 18395517 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationVerhoeven DH et al. (2008), NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways. Mol. Immunol., 45(15):3917-25.
PMID: 18657862 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayDulphy N et al. (2008), An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J. Immunol., 181(3):2227-37.
PMID: 18641363 -
Species: Human
Sample Types: Peptide
Applications: Surface Plasmon ResonanceKwong KY et al. (2008), Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity. J. Mol. Biol., 384(5):1143-56.
PMID: 18809410 -
Species: Human
Sample Types: Whole Cells
Applications: Functional AssayZhang H et al. (2007), 4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy. J. Immunol., 179(7):4910-8.
PMID: 17878391 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationShi J et al. (2007), Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood, 111(3):1309-17.
PMID: 17947507 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationKim YJ et al. (2007), 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells. Blood, 111(3):1378-86.
PMID: 18024793 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryRoda-Navarro P et al. (2006), Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. U.S.A., 103(30):11258-63.
PMID: 16849432 -
Species: Human
Sample Types: Recombinant Protein
Applications: NeutralizationHanabuchi S et al. (2006), Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 107(9):3617-23.
PMID: 16397134 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryBrando C et al. (2005), Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. J. Leukoc. Biol., 78(2):359-71.
PMID: 15937142 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationTerme M et al. (2005), BCR/ABL promotes dendritic cell-mediated natural killer cell activation. Cancer Res., 65(14):6409-17.
PMID: 16024645 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationDavis Z et al. (0), CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruse33(2):93-100.
PMID: 27296670
There are no citations that match your criteria.
Customer Reviews for Human NKG2D/CD314 Antibody (2)
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Application: FlowSample Tested: Peripheral blood mononuclear cells (PBMCs)Species: HumanVerified Customer | Posted 01/24/2021
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Application: IHCSample Tested: Paraffined tumor tissue from HCC xenograftSpecies: HumanVerified Customer | Posted 04/13/2018
There are no reviews that match your criteria.