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TrkC Products
Members of the Tyrosine Kinase Receptor (Trk) family (TrkA, TrkB, and TrkC) of receptor tyrosine kinases act as receptors for the neurotrophin family: BDNF, NGF, NT-3, and NT-4. Trks exhibit selectivity for specific neurotrophins. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a common structural organization consisting of an extracellular region with two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains, and an intracellular region that contains the tyrosine kinase domain. They are best known for their regulation of neuronal survival and axon outgrowth. TrkC is predominantly expressed in the central nervous system.
25 results for "TrkC" in Products
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TrkC Products
Members of the Tyrosine Kinase Receptor (Trk) family (TrkA, TrkB, and TrkC) of receptor tyrosine kinases act as receptors for the neurotrophin family: BDNF, NGF, NT-3, and NT-4. Trks exhibit selectivity for specific neurotrophins. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a common structural organization consisting of an extracellular region with two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains, and an intracellular region that contains the tyrosine kinase domain. They are best known for their regulation of neuronal survival and axon outgrowth. TrkC is predominantly expressed in the central nervous system.
25 results for "TrkC" in Products
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Simple Western, Western Blot |
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Simple Western, Western Blot |
Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
| Chemical Name : | N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| Purity : | ≥98% (HPLC) |
TrkB and TrkC agonist; brain penetrant
| Chemical Name : | 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #227403 |
| Applications : | Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #75219 |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Source : | NS0 |
| Accession # : | Q6VNS1 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Source : | NS0 |
| Accession # : | Q96CY4 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Flow Cytometry |
Potent and selective pan-Trk inhibitor; peripherally restricted
| Chemical Name : | N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #75213 |
| Applications : | Flow Cytometry |
