PF 06273340

Name: PF 06273340
Brand: Tocris Bioscience
SKU: 6115
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6115

Citations (2)

COA / SDS

Potent and selective pan-Trk inhibitor; peripherally restricted

Key Product Details

Description:	Potent and selective pan-Trk inhibitor; peripherally restricted
Chemical Name:	N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	479.93

View Full Technical Details for PF 06273340

Technical Data
Citations

Biological Activity for PF 06273340

PF 06273340 is a potent and selective pan-Trk inhibitor (IC₅₀ values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 06273340

PF 06273340 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 06273340

M. Wt	479.93
Formula	C₂₃H₂₂ClN₇O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1402438-74-7
PubChem ID	66571548
InChi Key	BPIWZDNVMQQBQX-UHFFFAOYSA-N
Smiles	NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06273340

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.99	100

Preparing Stock Solutions for PF 06273340

The following data is based on the product molecular weight 479.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for PF 06273340

References are publications that support the biological activity of the product.

Skerratt The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain. J.Med.Chem. 2016 PMID: 27766865