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TREM2 Products

TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a transmembrane protein that is expressed on newly differentiated and alternatively activated tissue macrophages, immature myeloid dendritic cells, and osteoclasts. TREM2 interacts with and modifies signaling through dendritic cell and osteoclast Plexin A1, a semaphorin receptor. It is active in several settings that involve membrane fusion, including phagocytosis of microbes by macrophages and apoptotic neurons by microglia, and formation of osteoclasts and multinucleated giant cells from macrophages. TREM2 signals through the adaptor protein DAP12 and can associate with the linker protein LAT2 to inhibit macrophage activaation. A soluble isoform of TREM2 antagonizes full-length TREM2 and is elevated in cerebrospinal fluid of patients with active multiple sclerosis.

41 results for "TREM2" in Products

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TREM2 Products

TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a transmembrane protein that is expressed on newly differentiated and alternatively activated tissue macrophages, immature myeloid dendritic cells, and osteoclasts. TREM2 interacts with and modifies signaling through dendritic cell and osteoclast Plexin A1, a semaphorin receptor. It is active in several settings that involve membrane fusion, including phagocytosis of microbes by macrophages and apoptotic neurons by microglia, and formation of osteoclasts and multinucleated giant cells from macrophages. TREM2 signals through the adaptor protein DAP12 and can associate with the linker protein LAT2 to inhibit macrophage activaation. A soluble isoform of TREM2 antagonizes full-length TREM2 and is elevated in cerebrospinal fluid of patients with active multiple sclerosis.

41 results for "TREM2" in Products

WB, ELISA, ICC, KO
ELISA, Flow, IHC, CyTOF-ready, ICC, KO

Simple Plex Cartridge Kit containing TREM2 for use with Human CCS/Plasma/Serum/CSF. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.

Flow
WB

Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies

ELISA
WB, ELISA, ICC
ELISA
WB, Flow, ICC
WB
BA
BA

Biotinylated

Flow
Catalog #: FAB17291U
Flow
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