Human/Mouse TREM2 APC-conjugated Antibody Best Seller

R&D Systems, part of Bio-Techne | Catalog # FAB17291A

Catalog #
Availability
Size / Price
Qty
FAB17291A
Print Quote
Bulk Order
Conjugate
Catalog #
Unconjugated
MAB17291
View Product
Alexa Fluor 350
FAB17291U
View Product
Alexa Fluor 405
FAB17291V
View Product
Alexa Fluor 488
FAB17291G
View Product
Alexa Fluor 532
FAB17291X
View Product
Alexa Fluor 594
FAB17291T
View Product
Alexa Fluor 647
FAB17291R
View Product
Alexa Fluor 700
FAB17291N
View Product
Alexa Fluor 750
FAB17291S
View Product
Alexa Fluor Plus 405
FAB17291AFP405
View Product
Alexa Fluor Plus 488
FAB17291AFP488
View Product
Alexa Fluor Plus 555
FAB17291AFP555
View Product
Alexa Fluor Plus 594
FAB17291AFP594
View Product
Alexa Fluor Plus 647
FAB17291AFP647
View Product
Alexa Fluor Plus 680
FAB17291AFP680
View Product
Allophycocyanin/Cy7
FAB17291APCCY7
View Product
Biotin
FAB17291B
View Product
CoraFluor 1
FAB17291CL1
View Product
DyLight 350
FAB17291D
View Product
DyLight 405
FAB17291E
View Product
DyLight 488
FAB17291K
View Product
DyLight 550
FAB17291L
View Product
DyLight 594
FAB17291M
View Product
DyLight 650
FAB17291W
View Product
DyLight 680
FAB17291Y
View Product
DyLight 755
FAB17291Z
View Product
FITC
FAB17291F
View Product
HRP
FAB17291H
View Product
Janelia Fluor 525
FAB17291JF525
View Product
Janelia Fluor 549
FAB17291I
View Product
Janelia Fluor 646
FAB17291J
View Product
Janelia Fluor 669
FAB17291JF669
View Product
mFluor Violet 450 SE
FAB17291MFV450
View Product
mFluor Violet 500 SE
FAB17291MFV500
View Product
mFluor Violet 610 SE
FAB17291MFV610
View Product
PE/Atto594
FAB17291PEATT594
View Product
PE/Cy5.5
FAB17291PECY55
View Product
PE/Cy7
FAB17291PECY7
View Product
PerCP
FAB17291C
View Product
Phycoerythrin
FAB17291P
View Product
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse, Transgenic Mouse

Applications

Validated:

Flow Cytometry

Cited:

Neutralization, Flow Cytometry, Immunocytochemistry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 237920

View all TREM2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse TREM-2
extracellular domain
Accession # Q99NH8

Specificity

Detects human and mouse TREM-2 in direct ELISAs and Western blots. Stains TREM-2 transfectants but not TREM-1 transfectants.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Scientific Data Images for Human/Mouse TREM2 APC-conjugated Antibody

Detection of TREM-2 antibody in RAW 264.7 Mouse Cell Line antibody by Flow Cytometry.

Detection of TREM‑2 in RAW 264.7 Mouse Cell Line by Flow Cytometry.

RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of TREM-2 antibody in Human Blood Monocytes antibody by Flow Cytometry.

Detection of TREM‑2 in Human Blood Monocytes by Flow Cytometry.

Human peripheral blood monocytes were stained with (A) Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A) or (B) isotype control antibody (Catalog # IC013A) followed by Mouse anti-Human Integrin alpha M/CD11b PE-conjugated Monoclonal Antibody (Catalog # FAB16991P). View our protocol for Staining Membrane-associated Proteins.
Detection of TREM-2 antibody in HEK Human Cell Line Transfected with Human TREM-2 and eGFP antibody by Flow Cytometry.

Detection of TREM‑2 in HEK Human Cell Line Transfected with Human TREM-2 and eGFP by Flow Cytometry.

HEK293 human embryonic kidney cell line transfected with either (A) human TREM-2 or (B) human TREM-1 and eGFP was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A). Quadrant markers were set based on control antibody staining (Catalog # IC013A). View our protocol for Staining Membrane-associated Proteins.

Applications for Human/Mouse TREM2 APC-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: RAW 264.7 mouse monocyte/macrophage cell line, human peripheral blood monocytes, and HEK293 human embryonic kidney cell line transfected with human TREM-2 and eGFP

Reviewed Applications

Read 2 reviews rated 4 using FAB17291A in the following applications:

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Spectra Viewer

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TREM2

TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa molecular weight type I transmembrane member of the TREM family and Ig superfamily . Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. Within the ECD, human TREM-2 shares 73% and 74% aa sequence identity with mouse and rat TREM-2, respectively. Two closely related transcripts were reported in mouse and designated TREM-2a and TREM-2b. Soluble forms of the TREM-2 ECD are generated by alternative splicing or proteolytic cleavage, and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. It is a pattern recognition receptor that binds anionic ligands. A positively charged lysine within the transmembrane segment allows association with the signal adapter protein, DAP12 to deliver an activating signal that plays a role in both innate and adaptive immune responses, including inhibition of macrophage activation. TREM-2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes. It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria. In the CNS, TREM-2 binds to ApoE, ApoA1, and ApoB and mediates the clearance of apoptotic neurons, amyloid plaques, and cell debris following demyelination. TREM-2 also interacts with and modifies signaling through Plexin A1 on dendritic cells and osteoclasts. Mutations in TREM-2 or DAP12 are associated with the development of Alzheimer's disease and Nasu-Hakola disease (NHD/PLOSL) which is characterized by presenile dementia and bone cysts. Soluble TREM-2 is elevated in cerebrospinal fluid of patients with active multiple sclerosis (MS), and TREM-2 blockade exacerbates disease symptoms in the experimental EAE model of MS.

Long Name

Triggering Receptor Expressed on Myeloid Cells 2

Alternate Names

PLOSL2, TREM-2

Entrez Gene IDs

54209 (Human); 102133279 (Cynomolgus Monkey)

Gene Symbol

TREM2

UniProt

Q99NH8 (Mouse)

Additional TREM2 Products

Product Documents for Human/Mouse TREM2 APC-conjugated Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human/Mouse TREM2 APC-conjugated Antibody

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.