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290 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
Recombinant Monoclonal Antibody.
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-TIM3-3113-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP2-79836-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]")
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-TIM3-3113-Immunohistochemistry-Paraffin-NBP2-79702-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]")
![Western Blot: TIM-3 Antibody (OTI2E2)Azide and BSA Free [NBP2-74520]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-OTI2E2-Azide-and-BSA-Free-Western-Blot-NBP2-74520-img0001.jpg "Western Blot: TIM-3 Antibody (OTI2E2)Azide and BSA Free [NBP2-74520]")
![Immunohistochemistry: TIM-3 Antibody (OTI2E2) [NBP2-45933]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-2E2-Immunohistochemistry-NBP2-45933-img0005.jpg "Immunohistochemistry: TIM-3 Antibody (OTI2E2) [NBP2-45933]")
Recombinant Monoclonal Antibody
Recombinant Monoclonal Antibody
![Immunocytochemistry/ Immunofluorescence: TIM-3 Antibody (2C12) - Chimeric - Azide and BSA Free [NBP3-11989]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-2C12-Chimeric-Immunocytochemistry-Immunofluorescence-NBP3-11989-img0001.jpg "Immunocytochemistry/ Immunofluorescence: TIM-3 Antibody (2C12) - Chimeric - Azide and BSA Free [NBP3-11989]")