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TGF-beta RIII Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

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74 results for "TGF-beta RIII" in Products

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TGF-beta RIII Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

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74 results for "TGF-beta RIII" in Products

WB, Flow, IHC, CyTOF-ready
WB
Catalog #: BAF5034
WB
Catalog #: MAB2421
Catalog #: RDC1421
Catalog #: RDC1363
IHC, IP, WB
ELISA, WB
IHC, WB
ELISA
Catalog #: NBP1-89988PEP
AC
ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

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