
TGF-beta RI/ALK-5 Products
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.
33 results for "TGF-beta RI/ALK-5" in Products
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TGF-beta RI/ALK-5 Products
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.
33 results for "TGF-beta RI/ALK-5" in Products
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name : | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
Purity : | ≥99% (HPLC) |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name : | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
Purity : | ≥98% (HPLC) |
Potent and selective inhibitor of TGF-βRI
Alternate Names : | E-616452, SJN 2511, ALK5 Inhibitor II |
Chemical Name : | 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
Purity : | ≥99% (HPLC) |
Selective inhibitor of TGF-βRI
Chemical Name : | 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline |
Purity : | ≥97% (HPLC) |
SB 431542 synthesized to cGMP guidelines
Chemical Name : | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
Purity : | ≥99% |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #141231 |
Applications : | Flow Cytometry |
Selective inhibitor of TGF-βRI
Alternate Names : | HTS 466284 |
Chemical Name : | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline |
Purity : | ≥99% (HPLC) |
Potent and selective inhibitor of TGF-βRI
Chemical Name : | 4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
Purity : | ≥98% (HPLC) |
Selective CK1 inhibitor. Also inhibits TGF-βRI
Chemical Name : | 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
Purity : | ≥99% (HPLC) |
ALK4 and ALK5 (TGFβRI) inhibitor
Alternate Names : | LY 2157299 |
Chemical Name : | 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
Purity : | ≥98% (HPLC) |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA, Immunocytochemistry/Immunofluorescence, Western Blot |
RepSox synthesized to Ancillary Material Grade
Alternate Names : | ALK5 Inhibitor II, SJN 2511, E-616452 |
Chemical Name : | 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
Purity : | ≥99% |
Source : | NS0 |
Accession # : | P36897 |
Applications : | Bioactivity |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name : | 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine |
Purity : | ≥98% (HPLC) |
Biotinylated
Source : | HEK293 |
Accession # : | P36897.1 |
Applications : | Bioactivity |
A 83-01 synthesized to Ancillary Material Grade
Chemical Name : | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
Purity : | ≥98% |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #141231R |
Applications : | Western Blot |
Potent and selective inhibitor of TGF-βRI
Chemical Name : | 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide |
Purity : | ≥98% (HPLC) |
Potent and selective inhibitor of TGF-βRI
Chemical Name : | 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide |
Purity : | ≥98% (HPLC) |
Potent TGF-βRI inhibitor
Chemical Name : | 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide |
Purity : | ≥98% (HPLC) |
Potent ATP-competitive TGF-βRI inhibitor
Chemical Name : | 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine |
Purity : | ≥98% (HPLC) |
Potent inhibitor of TGF-βRI
Chemical Name : | 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline |
Purity : | ≥98% (HPLC) |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #141229 |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |