Skip to main content

TGF-beta RI/ALK-5 Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

33 results for "TGF-beta RI/ALK-5" in Products

TGF-beta RI/ALK-5 Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

33 results for "TGF-beta RI/ALK-5" in Products

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Potent and selective inhibitor of TGF-βRI

Selective inhibitor of TGF-βRI

SB 431542 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI

Potent and selective inhibitor of TGF-βRI

Selective CK1 inhibitor. Also inhibits TGF-βRI

ALK4 and ALK5 (TGFβRI) inhibitor

WB, ELISA, ICC

RepSox synthesized to Ancillary Material Grade

Selective inhibitor of TGF-βRI, ALK4 and ALK7

BA

Biotinylated

A 83-01 synthesized to Ancillary Material Grade

WB
Catalog #: MAB5871R
WB

Recombinant Monoclonal Antibody.

Potent and selective inhibitor of TGF-βRI

Potent and selective inhibitor of TGF-βRI

Potent TGF-βRI inhibitor

Potent ATP-competitive TGF-βRI inhibitor

Potent inhibitor of TGF-βRI

WB
/ 2
Results Per Page
5 10 25 50