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Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

103 results for "Spike RBD Proteins and Enzymes" in Products

Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

103 results for "Spike RBD Proteins and Enzymes" in Products

HEK293 Expressed, High ACE-2 Binding

BA

CHO Expressed. Trimerization Domain

BA

Omicron Variant

BA

Delta Variant (India) L452R T478K

BA

Omicron Variant

BA

His-tag

BA

Omicron Variant His-tag

BA

Omicron Variant

BA

Omicron Variant Biotinylated

HEK293 Expressed, High ACE-2 Binding

BA

CHO Expressed, High ACE-2 Binding

BA

Omicron Variant His-tag

BA

Omicron Variant Biotinylated His-tag Avi-tag

BA
BA

N439K, E484K

BA

Delta Plus

BA

Lambda Variant L452Q, F490S

BA

Mu Variant

Mammalian CHO Cell Expressed, High ACE-2 Binding

BA

Omicron Variant His-tag

BA

Beta Variant (South Africa), K417N, E484K, N501Y

BA
BA

Kappa Variant L452R E484Q

BA

Omnicron Variant

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