Spike RBD: Proteins and Enzymes
The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.
108 results for "Spike RBD Proteins and Enzymes" in Products
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Spike RBD: Proteins and Enzymes
The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.
108 results for "Spike RBD Proteins and Enzymes" in Products
His-tag
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Delta Variant (India) L452R T478K
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
HEK293 Expressed, High ACE-2 Binding
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Kappa Variant L452R E484Q
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Tn5 Insect Cell Expressed, High ACE-2 Binding
Source : | T. ni (baculovirus) |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
His-tag
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Mammalian CHO Cell Expressed, High ACE-2 Binding
Source : | CHO |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
N439K, E484K
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | YP_003767.1 |
Applications : | Bioactivity |
Source : | CHO |
Accession # : | QHR63300.2 |
Applications : | Bioactivity |
Biotinylated via Amines
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Sf21 Expressed, High ACE-2 Binding
Source : | Sf 21 (baculovirus) |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
N501Y Mutation found in Alpha, Beta, and Gamma Variants
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Source : | CHO |
Accession # : | QHR63300.2 |
Applications : | Bioactivity |
CHO Expressed, High ACE-2 Binding
Source : | CHO |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Mammalian CHO Cell Expressed
Source : | CHO |
Accession # : | NP_828851.1 |
Applications : | Bioactivity |
Delta Variant (India)
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
His-tag Delta Variant (India) L452R T478K
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Biotinylated
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Lambda Variant
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
His-tag Biotinylated N501Y Mutation found in Alpha, Beta, and Gamma Variants
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Kappa Variant L452R E484Q
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |
Omicron Variant His-tag
Source : | HEK293 |
Accession # : | YP_009724390.1 |
Applications : | Bioactivity |