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Spike RBD Products

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

144 results for "Spike RBD" in Products

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Spike RBD Products

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

144 results for "Spike RBD" in Products

HEK293 Expressed, High ACE-2 Binding

Block

CHO Expressed. Trimerization Domain

ICC

Recombinant Monoclonal Antibody.

WB
BA

His-tag

BA

Delta Variant (India) L452R T478K

ELISA, Block

Detects SARS-CoV-2 Spike RBD and Spike S1 in sandwich ELISAs

Block, ICC
BA
BA

Omicron Variant His-tag

BA

Delta Plus

ELISA, Block
WB, Simple Western
ICC
BA

Omicron Variant

RUO Quantitative ELISA. Patent Pending.

BA

Beta Variant (South Africa), K417N, E484K, N501Y

BA

Delta Plus

Block

Recombinant Monoclonal Antibody. His-tagged VHH domain.

ELISA, Block

Detects SARS-CoV-2 Spike RBD and Spike S1 in sandwich ELISAs

Catalog #: DSR200-CE
ELISA

Available in the EU and UK only. For research testing.

Catalog #: COV219-100
BA

Biotinylated via Amines

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