Sign In / Register
SHP-1 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
7 results for "SHP-1" in Products
Application
Product Action
Conjugates
Clonality
Host Species
Isotype
Low Endotoxin
Sample Size
Citations
Reviews
SHP-1 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
7 results for "SHP-1" in Products
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
WB, Simple Western
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Simple Western, Western Blot |
Potent inhibitor of shp2 and shp1 PTP
| Chemical Name : | 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid |
| Purity : | ≥98% (HPLC) |
Non-competitive protein tyrosine phosphatase inhibitor
| Chemical Name : | 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
| Purity : | ≥98% (HPLC) |
ICC
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #255402 |
| Applications : | Immunocytochemistry/Immunofluorescence |
Catalog #:
1878-SH
EnzAct
| Source : | E. coli |
| Accession # : | P29350 |
| Applications : | Enzyme Activity |
