11 results for "Ras Small Molecules and Peptides" in Products
Ras Small Molecules and Peptides
The Ras proteins (H-Ras, N-Ras, and two splice variants of K-Ras) define a closely related family of 21 kDa GTPases that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. Receptor tyrosine kinases and G-protein coupled receptors activate Ras, and effectors include Raf and PI 3-kinase. Activating mutations of Ras, which impair GTPase activity and stabilize the active state, are found in nearly one-third of all human cancers.
Potent farnesyl diphosphate (FPP) synthase inhibitor
Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
Selective KRAS Degrader (PROTAC®)
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Ras signaling inhibitor; inhibits Ack1 and GCK
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
Negative control for LC 2 (Cat. No. 7420)
Mutation-selective inhibitor of KRASG12C
Potent and selective KRASG12C inhibitor
PDEδ autophagy-tethering compound (ATTEC) Degrader
