BC-LI-0186

Tocris Bioscience, part of Bio-Techne | Catalog # 6791

Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
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Key Product Details

Description

Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

View all Ras GTPase Inhibitors »

Product Description

BC-LI-0186 is a potent and high affinity leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor (IC50 = 46.1 nM; Kd = 42.1 nM for binding to LRS). Inhibits mTOR complex 1 activity by blocking binding to LRS without affecting catalytic activity. Inhibits leucine-induced translocation of LRS to the lysosome.

Product Specifications

Molecular Weight

429.54

Formula

C22H27N3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide

CAS Number

695207-56-8

PubChem ID

4917788

InChI Key

SQYWMHPZMHDCHP-UHFFFAOYSA-N

SMILES

CC(C1=C(N(N(C2=CC=C(S(=O)(NCCOC3=CC=CC=C3)=O)C=C2)C1=O)C)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.95 100

Preparing Stock Solutions for BC-LI-0186

The following data is based on the product molecular weight 429.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BC-LI-0186

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BC-LI-0186

For research use only

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