Fendiline Hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6407

Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
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Key Product Details

Description

Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker

View all Ras GTPase Inhibitors »

Product Description

Fendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).

Product Specifications

Molecular Weight

351.91

Formula

C23H25N.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride

CAS Number

13636-18-5

PubChem ID

5702162

InChI Key

NJXWZWXCHBNOOG-UHFFFAOYSA-N

SMILES

CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.19 100
Ethanol 7.04 20

Preparing Stock Solutions for Fendiline Hydrochloride

The following data is based on the product molecular weight 351.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Fendiline Hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fendiline Hydrochloride

For research use only

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