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64 results for "Raf-1" in Products

Raf-1 Products

Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.

Potent, selective c-Raf1 kinase inhibitor

Chemical Name: 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
Purity: ≥95% (HPLC)
Potent, selective c-Raf1 kinase inhibitor

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

Chemical Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

Potent BRAF and CRAF inhibitor

Chemical Name: N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Purity: ≥98% (HPLC)
Potent BRAF and CRAF inhibitor
Reactivity: Human, Rat
Details: Mouse IgG2b Kappa Monoclonal Clone #1H4
Applications: WB, ELISA, Func, Mycoplasma
Western Blot: Raf-1 Antibody (1H4) [H00005894-M03]
(6)
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Chemical Name: 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
Purity: ≥98% (HPLC)
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Recombinant Monoclonal Antibody

Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Monoclonal Clone #SR2181
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2a Monoclonal Clone #563002

Potent Raf kinase inhibitor

Chemical Name: 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide
Purity: ≥98% (HPLC)
Potent Raf kinase inhibitor
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Monoclonal Clone #23GB2640
Applications: WB, ICC/IF, Flow, Mycoplasma
Reactivity: Human
Details: Mouse IgG Polyclonal
Applications: WB, ICC/IF
Western Blot: Raf-1 Antibody [H00005894-B01P]
(2)
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: IHC, ICC/IF
Immunocytochemistry/ Immunofluorescence: Raf-1 Antibody [NBP1-85462]
(5)
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