Raf-1 Antibody (563002) [PE]
Novus Biologicals, part of Bio-Techne | Catalog # FAB4540P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Label
PE (Excitation = 488 nm, Emission = 575 nm)
Antibody Source
Monoclonal Mouse IgG2A Clone # 563002
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
E. coli-derived recombinant human Raf-1
Asn189-Thr353
Accession # P04049
Asn189-Thr353
Accession # P04049
Specificity
Detects human, mouse, and rat Raf-1 at 74 kDa in Western blots.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Raf-1 Antibody (563002) [PE]
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
PBS
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Raf-1
Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.
Long Name
v-raf-1Murine Leukemia Viral Oncogene Homolog 1
Alternate Names
c-Raf-1, Raf1, v-Raf-1
Gene Symbol
RAF1
Additional Raf-1 Products
Product Documents for Raf-1 Antibody (563002) [PE]
Product Specific Notices for Raf-1 Antibody (563002) [PE]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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