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PARP Products
PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
35 results for "PARP" in Products
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PARP Products
PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
35 results for "PARP" in Products
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #839120 |
| Applications : | Immunohistochemistry, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
Potent fluorescent PARP inhibitor; cell permeable
| Chemical Name : | (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron |
| Purity : | ≥90% (HPLC) |
High affinity PARP-1 and -2 inhibitor; orally bioavailable
| Alternate Names : | ABT-888 |
| Chemical Name : | 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Potent tankyrase inhibitor
| Alternate Names : | XAV939 Wnt Signaling Inhibitor |
| Chemical Name : | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity : | ≥98% (HPLC) |
PARP-1 inhibitor
| Chemical Name : | Pyridine-3-carboxamide |
| Purity : | ≥99% (HPLC) |
Fluorescent NAD+; substrate for ADP-ribosylation for use in PARP assays
| Chemical Name : | β-Nicotinamide-N6-[2-[[6-[fluorescein]-amino]-2-oxohexyl-hexyl]amino]-2-oxoethyl]adenine dinucleotide |
Potent PARP inhibitor
| Chemical Name : | 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Purity : | ≥98% (HPLC) |
Biotinylated-NAD+; substrate for ADP-ribosylation
| Chemical Name : | β-Nicotinamide-N6-[2-[[6-[biotinyl]amino]hexyl]amino]-2-oxoethyl]adenine dinucleotide |
PARP inhibitor; cytoprotectant
| Chemical Name : | N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Potent PARP inhibitor
| Chemical Name : | N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride |
| Purity : | ≥98% (HPLC) |
XAV 939 synthesized to cGMP guidelines
| Chemical Name : | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Purity : | ≥99% |
Potent PARP inhibitor; orally bioavailable
| Chemical Name : | 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone |
| Purity : | ≥98% (HPLC) |
Biotinylated analog of β-NAD+; commonly used reagent in LSD1 and PARP1 assays
| Alternate Names : | 6-Biotin-17-NAD |
| Chemical Name : | β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide sodium salt |
| Purity : | ≥95% (HPLC) |
Potent PARP-1 inhibitor
| Chemical Name : | 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride |
| Purity : | ≥99% (HPLC) |
Selective allosteric PARP14 inhibitor
| Chemical Name : | N-[2-(9H-Carbazol-1-yl)phenyl]acetamide |
| Purity : | ≥98% (HPLC) |
PARP inhibitor
| Alternate Names : | CO-338 |
| Chemical Name : | 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid |
| Purity : | ≥98% (HPLC) |
Potent PARP1 Degrader (PROTAC®)
| Chemical Name : | N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide |
| Purity : | ≥98% (HPLC) |
PARP inhibitor; photoaffinity probe
| Chemical Name : | 3-(3-Butyn-1-yl)-N-[5-cyano-6-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinyl]-3H-diazirine-3-propanamide |
| Purity : | ≥95% (HPLC) |
PARP14 inhibitor; cell-permeable
| Chemical Name : | 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid |
| Purity : | ≥98% (HPLC) |
Selective PARP-10 inhibitor
| Chemical Name : | 4,4'-Oxybis[benzamide] |
| Purity : | ≥98% (HPLC) |
Nicotinamide synthesized to Ancillary Material Grade
| Chemical Name : | Pyridine-3-carboxamide |
| Purity : | ≥99% |
Tankyrase inhibitor
| Chemical Name : | N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
| Purity : | ≥98% (HPLC) |
Negative control for SK 575 (Cat. No. 7583)
| Chemical Name : | 12-(4-(2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-N-(2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-oxododecanamide |
| Purity : | ≥98% (HPLC) |
