87 results for "Orexin R2/HCRTR2" in Products
Orexin R2/HCRTR2 Products
Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.
Potent and selective OX2 antagonist
![Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01]](https://resources.rndsystems.com/images/products/Orexin-R2-HCRTR2-Antibody-1E3-Western-Blot-H00003062-M01-img0006.jpg "Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01]")
Potent and selective OX2 agonist
Selective OX2 antagonist
Potent and selective OX2 agonist
Potent, dual orexin receptor antagonist
Highly potent and selective OX2 antagonist; brain penetrant
Potent and selective OX1 antagonist
![Western Blot: Orexin R2/HCRTR2 Overexpression Lysate [NBP2-04198]](https://resources.rndsystems.com/images/products/Orexin-Receptor-2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-04198-img0001.jpg "Western Blot: Orexin R2/HCRTR2 Overexpression Lysate [NBP2-04198]")
![Western Blot: Orexin R2/HCRTR2 Antibody [NB100-74579]](https://resources.rndsystems.com/images/products/Orexin-R2-HCRTR2-Antibody-Western-Blot-NB100-74579-img0003.jpg "Western Blot: Orexin R2/HCRTR2 Antibody [NB100-74579]")