JNJ 10397049

Name: JNJ 10397049
Brand: Tocris Bioscience
SKU: 4317

Tocris Bioscience, part of Bio-Techne | Catalog # 4317

Citations (13)

COA / SDS

Selective OX2 antagonist

Key Product Details

Description:	Selective OX₂ antagonist
Chemical Name:	N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea
Purity:	≥98% (HPLC)
Molecular Weight:	484.18

View Full Technical Details for JNJ 10397049

Technical Data
Citations

Biological Activity for JNJ 10397049

JNJ 10397049 is a selective OX₂ receptor antagonist (pIC₅₀ = 7.4 for chimeric OX₂ receptors; pK_B values are 5.9 and 8.5 for OX₁ and OX₂ receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX₂ receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Compound Libraries for JNJ 10397049

JNJ 10397049 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 10397049

M. Wt	484.18
Formula	C₁₉H₂₀Br₂N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	708275-58-5
PubChem ID	9869934
InChi Key	RBKIJGLHFFQHBE-IRXDYDNUSA-N
Smiles	O=C(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)NC1=C(Br)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 10397049

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	100

Preparing Stock Solutions for JNJ 10397049

The following data is based on the product molecular weight 484.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.33 mL	20.65 mL
5 mM	0.41 mL	2.07 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for JNJ 10397049

References are publications that support the biological activity of the product.

Tran Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists. Eur.J.Pharmacol. 2011 PMID: 21679703
Gozzi Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists. PLoS ONE 2011 PMID: 21307957
Dugovic Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J.Pharmacol.Exp.Ther. 2009 PMID: 19363060