ACT 335827
Tocris Bioscience, part of Bio-Techne | Catalog # 4983
Potent and selective OX1 antagonist
Key Product Details
Description
Potent and selective OX1 antagonist
Product Description
ACT 335827 is a potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.Product Specifications
Molecular Weight
518.64
Formula
C31H38N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
CAS Number
1354039-86-3
PubChem ID
54765113
InChI Key
HXHOBPVRRPCTLG-SETSBSEESA-N
SMILES
O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.86 | 100 | |
| Ethanol | 51.86 | 100 |
Preparing Stock Solutions
for ACT 335827
The following data is based on the product molecular weight 518.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.64 mL | 19.28 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Steiner Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 2013 PMID: 23589487
Product Specific Notices for ACT 335827
For research use only
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