Nrf2: Small Molecules and Peptides
NF-E2 related factor 2 (Nrf2) is a member of the cap 'n collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.
7 results for "Nrf2 Small Molecules and Peptides" in Products
7 results for "Nrf2 Small Molecules and Peptides" in Products
Nrf2: Small Molecules and Peptides
NF-E2 related factor 2 (Nrf2) is a member of the cap 'n collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.
Covalent allosteric NRF2 inhibitor
| Chemical Name: | 1-[(3R)-3-[3-(4-Amino-1,3,5-triazin-2-yl)-5-chlorophenyl]-4-morpholinyl]-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Nrf2 inhibitor; phenotypically lethal
| Chemical Name: | N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide |
| Purity: | ≥98% (HPLC) |
Nrf2 activator
| Chemical Name: | N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea |
| Purity: | ≥98% (HPLC) |
Nrf2 activator; inhibits Nrf2/Keap1 interaction
| Chemical Name: | (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Nrf2 signaling activator
| Chemical Name: | 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole |
| Purity: | ≥98% (HPLC) |
PGK1 inhibitor; activates Nrf2
| Chemical Name: | (3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide |
| Purity: | ≥98% (HPLC) |
Nrf2 activator; cell permeable
| Chemical Name: | 2-Methylenebutanedioic acid 4-octyl ester |
| Purity: | ≥98% (HPLC) |
