RA 839
Tocris Bioscience, part of Bio-Techne | Catalog # 5707
Nrf2 activator; inhibits Nrf2/Keap1 interaction
Key Product Details
Description
Nrf2 activator; inhibits Nrf2/Keap1 interaction
Product Description
RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.Product Specifications
Molecular Weight
452.57
Formula
C25H28N2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
CAS Number
1832713-02-6
PubChem ID
91971266
InChI Key
BVYWIQHJXAEJOD-IBGZPJMESA-N
SMILES
CC1=C(C)C=C(C)C(C)=C1S(=O)(NC2=C(C=CC=C3)C3=C(N4C[C@@H](C(O)=O)CC4)C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.26 | 100 |
Preparing Stock Solutions
for RA 839
The following data is based on the product molecular weight 452.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.10 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Winkel Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 2015 PMID: 26459563
Product Specific Notices for RA 839
For research use only
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