4-Octyl itaconate

Name: 4-Octyl itaconate
Brand: Tocris Bioscience
SKU: 6662
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6662

(1)

Citations (12)

COA / SDS

Nrf2 activator; cell permeable

Key Product Details

Description:	Nrf2 activator; cell permeable
Chemical Name:	2-Methylenebutanedioic acid 4-octyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	242.31

View Full Technical Details for 4-Octyl itaconate

Technical Data
Citations / Reviews (1)

Biological Activity for 4-Octyl itaconate

4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.

Compound Libraries for 4-Octyl itaconate

4-Octyl itaconate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-Octyl itaconate

M. Wt	242.31
Formula	C₁₃H₂₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3133-16-2
PubChem ID	14239884
InChi Key	KBASUIDPDITQHT-UHFFFAOYSA-N
Smiles	CCCCCCCCOC(CC(C(O)=O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-Octyl itaconate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.23	100

Preparing Stock Solutions for 4-Octyl itaconate

The following data is based on the product molecular weight 242.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.13 mL	20.63 mL	41.27 mL
5 mM	0.83 mL	4.13 mL	8.25 mL
10 mM	0.41 mL	2.06 mL	4.13 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 4-Octyl itaconate

References are publications that support the biological activity of the product.

Mills Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 2018 PMID: 29590092