ML 385
Tocris Bioscience, part of Bio-Techne | Catalog # 6243
Nrf2 inhibitor; phenotypically lethal
Product Description
ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.Product Specifications
Molecular Weight
511.59
Formula
C29H25N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
CAS Number
846557-71-9
PubChem ID
1383822
InChI Key
LINHYWKZVCNAMQ-UHFFFAOYSA-N
SMILES
CC1=C(C2=CC=C3N(C(C4=C(C=CC=C4)C)=O)CCC3=C2)N=C(S1)NC(CC5=CC=C6OCOC6=C5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.58 | 50 |
Preparing Stock Solutions
for ML 385
The following data is based on the product molecular weight 511.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.91 mL | 19.55 mL | 39.09 mL |
| 2.5 mM | 0.78 mL | 3.91 mL | 7.82 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Singh Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem.Biol. 2016 PMID: 27552339
Product Specific Notices for ML 385
For research use only
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