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NF-L Products
Neurofilaments are intermediate filaments that are major components of the neuronal cytoskeleton. Neurofilaments are composed of three subunits: the heavy subunit (NF-H), medium subunit (NF-M), and light subunit (NF-L). Neurofilaments are trimers that always contain the 68 kDa NF-L and variably contain 125 kDa NF-M and 200 kDa NF-H. The human neurofilament heavy chain is a phosphorylated cytoskeletal intermediate filament protein that is expressed in neurons. The neurofilament medium subunit Human NF-M is a phosphorylated glycoprotein that belongs to the type IV intermediate filament family. NF-L is a 68 kDa light chain cytoskeletal intermediate filament protein that associates with the 125 kDa NF-M and the 200 kDa NF-H to form neurofilaments.
All three neurofilament subunits share a common structure, with globular head, alpha-helical rod, and carboxy terminal side-arm domains. The subunits assemble to form 10 nm neurofilaments. Accumulation of neurofilaments is seen in several human diseases including amyotrophic lateral sclerosis (ALS), Parkinsons disease, Alzheimers disease, and diabetic neuropathy.
14 results for "NF-L" in Products
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NF-L Products
Neurofilaments are intermediate filaments that are major components of the neuronal cytoskeleton. Neurofilaments are composed of three subunits: the heavy subunit (NF-H), medium subunit (NF-M), and light subunit (NF-L). Neurofilaments are trimers that always contain the 68 kDa NF-L and variably contain 125 kDa NF-M and 200 kDa NF-H. The human neurofilament heavy chain is a phosphorylated cytoskeletal intermediate filament protein that is expressed in neurons. The neurofilament medium subunit Human NF-M is a phosphorylated glycoprotein that belongs to the type IV intermediate filament family. NF-L is a 68 kDa light chain cytoskeletal intermediate filament protein that associates with the 125 kDa NF-M and the 200 kDa NF-H to form neurofilaments.
All three neurofilament subunits share a common structure, with globular head, alpha-helical rod, and carboxy terminal side-arm domains. The subunits assemble to form 10 nm neurofilaments. Accumulation of neurofilaments is seen in several human diseases including amyotrophic lateral sclerosis (ALS), Parkinsons disease, Alzheimers disease, and diabetic neuropathy.
14 results for "NF-L" in Products
Simple Plex Cartridge Kit for quantitation of NF-L. Includes wash buffer and sample diluent SD13. For use with the Ella automated immunoassay system.
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Simple Plex Cartridge Kit for quantitation of NF-L. Includes wash buffer and sample diluent SD13. For use with the Ella automated immunoassay system.
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #1033955 |
| Applications : | Dual RNAscope ISH-IHC, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #268014 |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #1033926 |
| Applications : | Immunohistochemistry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #985912 |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #1002615 |
| Applications : | Immunohistochemistry, Western Blot |
Simple Plex Rat NF-L assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #985917 |
| Applications : | Immunocytochemistry/Immunofluorescence |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #1033901 |
| Applications : | Dual RNAscope ISH-IHC, Immunocytochemistry/Immunofluorescence, Immunohistochemistry |
