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IL-17C Products
Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.
25 results for "IL-17C" in Products
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IL-17C Products
Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.
25 results for "IL-17C" in Products
| Source : | E. coli |
| Accession # : | Q9P0M4.1 |
| Applications : | Binding Activity |
| Assay Range : | 125 - 8,000 pg/mL |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Source : | E. coli |
| Accession # : | Q8K4C5.1 |
| Applications : | Binding Activity |
| Source : | CHO |
| Accession # : | Q9P0M4 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311523 |
| Applications : | Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #311522 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #177114 |
| Applications : | Flow Cytometry |
