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IL-17C Products

Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.

 

25 results for "IL-17C" in Products

IL-17C Products

Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.

 

25 results for "IL-17C" in Products

BA
WB, IHC, CyTOF-ready, ICFlow
Catalog #: IC1234G
ICFlow
Catalog #: AF1234
WB
WB
Catalog #: IC1234N
ICFlow
WB
WB
Catalog #: IC1234S
ICFlow
Catalog #: IC1234T
ICFlow
Catalog #: IC1234R
ICFlow
Catalog #: IC1234V
ICFlow
Catalog #: IC1234U
ICFlow
Catalog #: IC23061R
ICFlow
Catalog #: IC23061N
ICFlow
Catalog #: IC23061U
ICFlow
Catalog #: IC23061S
ICFlow
Catalog #: IC23061G
ICFlow
Catalog #: IC23061T
ICFlow
Catalog #: IC23061V
ICFlow
CyTOF-ready, ICFlow
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